Discover Akura™ Flow 384 Multi-Organ Platform
Originating from prototypes conceived as part of the EU Body-on-a-Chip Project, the Akura™ Flow 384 Microplate is the most scalable multi-organ system engineered to be compatible with spheroids and organoids including our complete portfolio of 3D InSight™ Microtissues. Its flexibiity is opening the door to a nearly unlimited variety of pre-clinical efficacy and toxicity testing applications in a multi-tissue, microfluidic assay format. The Akura™ Flow microphysiological system provides experimental continuity between single- and multi-tissue testing applications, enabling the seamless integration and optimal utilization of standardized 3D models.
- 24 units per plate, each comprising 12 compartments for flexible combination of different organ models
- Standard plate format enabling spheroid/organoid to loaded through pick-and-place using automated liquid handlers
- A unique ULA coating in the compartments and microchannel preserves spheroid/organoid morphology in long-term culture
- Enhanced imaging speed and resolution through flat and highly transparent bottom"
Experience a highly flexible multi-organ platform:
- Conical well design with SureXchange™ ledge for easy gravity-based loading and access of spheroids
- Quick plug-and-play assembly of different microtissue types and seamless integration of additional models in the future
- Spheroid compartment with minimal dead volume enabling very precise medium exchange and drug treatment and low experimental variation
Rely on universal plate standards and low operational complexity:
- ANSI/SLAS standard format for quick implementation with widely used lab tools
- Full compatibility and with automation and robotic liquid handlers
- Gravity-based and pumpless flow control for simple plate handling
Access a wide range of readout methods:
- Anytime access to supernatants using manual or automated pipetting
- Parallel retrieval of spheroids for lytic assays, histology or RNA sequencing
- In-situ high-content imaging with minimal optical aberration with a flat and transparent PS bottom
Applications of Akura™ Flow 384 Multi-Organ Platform
- Signaling between Healthy and Diseased Tissue
- Pro-drug Activation and Drug-drug Interaction
- Metabolite Toxicity on On-target and Off-target Tissues
- Metabolite Disease Syndrome modeling combining for example liver, islet and adipose models
Akura™ Flow 384 Starter Kit
Bring Akura™ Flow 384 Microplate into your lab by acquiring our starter kit offering. It’s everything you need to immediately begin investigating complex biological questions in your research:
Akura™ Flow Programmable All-In-One Tilter
Controls gravity-based flow in incubator with intuitive built-in user interface
5x Pack of Akura™ Flow 384
Pack of 5 plates for up to 24 experimental conditions per plate
Akura™ Tilting Stand
Simple handling tool providing gravity-based flow while performing medium exchange under the hood
20x Pack of Akura™ 96 Microplate
For 3D spheroid aggregation before transferring into Akura™ Flow 384 or for collection after experiments and downstream analysis
1h Akura™ e-Introduction
Learn about concept, design and characteristics of the Akura™ Flow 384 Platform
Akura™ Organ-on-Chip Training & Support
Personal support and consulting to set up the first experiments with InSphero’s scientific experts
Akura™ Organ-on-Chip Technology Access Package
Allows for discounted Refills & Voucher (2000 CHF) for InSphero products (valid 6 months)
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