Human-Liver-Microtissues - InSphero


Time dependent changes in IC50 values in 3D InSight™ Human Liver Microtissues for a subset of compounds tested at day 5-6 and 14 of treatment. Lower IC50 values were obtained with 21 out of 38 drugs for which cell viability was determined at days 5-6 (striped) and 14 days (solid black). DILI severity category (1 severe → 5 No DILI) in brackets. Data are n=1 or geomean of n=2-16