Mechanistic Assays | InSphero

3D InSight™ Liver Microtissues are a powerful, predictive tool for investigating potential mechanisms of toxicity and thoroughly evaluating risks before moving drug candidates into animal studies and clinical trials.

Mechanistic Toxicology Applications

Human Liver Spheroid model for toxicology testing

Mitochondrial Toxicity

Assess mitochondrial liabilities and classify compound toxicity.

Human Liver Spheroid model for toxicology testing

Inflammation-mediated Toxicity

Detect potential indirect hepatotoxicity by inducing an inflammatory response.

Human Liver Spheroid model for toxicology testing

CYP-mediated Toxicity

Determine involvement of P450 cytochromes in hepatotoxicity.

Human Liver Spheroid model for toxicology testing

Cholestasis

Predict cholestasis by co-exposure of drugs with bile acids.

Human Liver Spheroid model for toxicology testing

Drug-induced Steatosis

Evaluate effects of drug-induced lipid accumulation.

Human Liver Spheroid model for toxicology testing

Apoptosis

Utilize Caspase 3/7 activation as a sensitive marker for hepatotoxicity.

Human Liver Spheroid model for toxicology testing

Omics Profiling

Detect changes in gene and protein expression over time and various dose levels.

InSphero Solutions

Microtissue Models and Kits

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Brochure: Solutions for Toxicology

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Poster: Drug Safety Assessment with Liver Microtissues

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of toxicity more efficiently.

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