Mechanistic Assays | InSphero

3D InSight™ Liver Microtissues are a powerful, predictive tool for investigating potential mechanisms of toxicity and thoroughly evaluating risks before moving drug candidates into animal studies and clinical trials.

Mechanistic Toxicology Applications

Mitochondrial Toxicity

Assess mitochondrial liabilities and classify compound toxicity.

Inflammation-mediated Toxicity

Detect potential indirect hepatotoxicity by inducing an inflammatory response.

CYP-mediated Toxicity

Determine involvement of P450 cytochromes in hepatotoxicity.

Cholestasis

Predict cholestasis by co-exposure of drugs with bile acids.

Drug-induced Steatosis

Evaluate effects of drug-induced lipid accumulation.

Apoptosis

Utilize Caspase 3/7 activation as a sensitive marker for hepatotoxicity.

Omics Profiling

Detect changes in gene and protein expression over time and various dose levels.

InSphero Solutions

Microtissue Models and Kits

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Brochure: Solutions for Toxicology

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Poster: Drug Safety Assessment with Liver Microtissues

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