Trovafloxacin - InSphero


Toxicity of Trovafloxacin in presence of inflammation. 3D InSight™ Human Liver Microtissues (co-culture model with human Kupffer cells), were treated with Trovafloxacin and the structurally related compound Levofloxacin in presence or absence of LPS. Synergistic toxicity of inflammation with a compound was only observed for Trovafloxacin, but not with the clinically safe drug Levofloxacin. Figure adapted from (3).