Increase translational relevance with physiologically relevant tumor models
3D-cell-based assays can be a powerful tool in oncology drug discovery and efficacy testing. However, their predictive value depends on how closely a model reflects the in vivo tumor microenvironment and cancer progression. 3D InSight™ Tumor Microtissues can better reflect the cell composition, inter-cellular interaction, tissue structure, and biological characteristics of primary tumors, and are amenable to a variety of biochemical and phenotypic endpoints to help you evaluate and optimize drug potency and efficacy testing.
Efficacy Testing Applications
Combinatorial Drug Testing
Use combinatorial anti-cancer drug efficacy testing to identify synergistic effects
Related Publications
Three‐dimensional microtissues essentially contribute to preclinical validations of therapeutic targets in breast cancer
Natalie Falkenberg, Ines Höfig, Michael Rosemann, Justine Szumielewski, Sabine Richter, Kenji Schorpp, Kamyar Hadian, Michaela Aubele, Michael J. Atkinson, Nataša Anastasov. Cancer Med. 2016 Apr; 5(4): 703–710. Published online 2016 Jan 14. doi: 10.1002/cam4.630
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Nataša Anastasov, Ines Höfig, Vanja Radulović, Simon Ströbel, Michael Salomon, Jan Lichtenberg, Ina Rothenaigner, Kamyar Hadian, Jens M. Kelm, Christian Thirion, Michael J. Atkinson
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3D tumor spheroid models for in vitro therapeutic screening: a systematic approach to enhance the biological relevance of data obtained
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High-content assays for characterizing the viability and morphology of 3D cancer spheroid cultures.
Sirenko O, Mitlo T, Hesley J, Luke S, Owens W, Cromwell EF. Assay Drug Dev Technol. 2015 Sep;13(7):402-14. doi: 10.1089/adt.2015.655.
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