Other Oncology - Antibody penetration
Antibody Penetration
Assess penetration of antibodies and engineered antibody fragments in vitro
Antibody penetration and distribution of biologics depend on a variety of factors, such as tissue density, antibody affinity, antigen density per cell, and physio-chemical properties. 3D InSight™ Tumor Microtissues offer a unique in vitro tool for assessing and optimizing penetration kinetics of antibodies and engineered antibody fragments.
- Test the kinetics of antibody penetration and distribution into scaffold-free 3D tumor microtissues by immunofluorescence
- Utilize biomimetic complex tumor models with native-like ECM and tissue density
- Improve therapeutic indices by assessing preclinical candidates for their ability to penetrate solid in vivo-like tumor microtissue in vitro
Example Data
Assess antibody penetration kinetics. Immunofluorescence of cryosections from BT-474 breast cancer microtissues showing the penetration and distribution of a tested antibody after 1 hour of treatment.
