Diabetes: Innovations, Outcomes, and Personalized Therapies (Keystone X3 2019) | InSphero

Diabetes: Innovations, Outcomes, and Personalized Therapies (Keystone X3 2019)


Mar 03 - 07, 2019

Advancing diabetes disease modeling

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Meet InSphero Advisory Board Member Dr. Patrick Guye at the Keystone Symposium on Diabetes: Innovations, Outcomes and Personalized Therapies.  Patrick will be available throughout the meeting to discuss the latest advances in 3D in vitro models for studying type 1 and type 2 diabetes:

  • 3D InSight™ Diabetes Discovery Platform
  • Tools for studying β-cell proliferation
  • Organ-on-a-chip applications for static and dynamic study of compound response in pancreatic β-cells

Schedule a Meeting

Standardized Islets for TD1 and TD2 Discovery

Thursday, March 7, 8–11 AM
Epigenomics of T2D Poster Session 

Patrick will present the latest data produced using our 3D InSight™ Diabetes Discovery Platform, which is based on a highly standardized islet model produced by optimized dissociation and controlled scaffold-free reaggregation of primary islet cells.  This process allows for precise control over newly forming islet microtissue size and eliminates contaminating exocrine materials while ensuring homogeneous, native-like distribution of endocrine cells within each tissue.

Patrick will provide an overview of how our islet microtissues are produced and characterized, and discuss applications, such as:

    • Static and dynamic study of compound release
    • Assessment of β-cell proliferation
    • Highly efficient viral transduction
    • Evaluation of cytokine and immune-cell-induced injury in Type 1 diabetes modeling
    • Assessment of glucolipotoxicity in Type 2 diabetes modeling

Conference Detail

Keystone Symposium X3: Diabetes Innovations, Outcomes, and Personalized Therapies
March 3-7, 2019
Whistler Convention Center
Whistler, BC CAN

Program Information
View the X3 Symposium Flyer
Review the X3 Symposium Program