3D InSight™ Rat Islet Microtissues, Rat Islet Model | InSphero

A standardized in vitro rat islet model for translational diabetes studies and toxicity testing

InSphero 3D InSight™ Rat Islet Microtissues are currently in the final stages of product development and quality control testing. If you are interested in beta testing this product to help us further characterize the model and develop useful endpoints, please click on the Get Started button below to contact us.

  • Expand your GSIS assay window and improve sensitivity to insulin secretagogues with a long-lived, robust model persisting > 28 days in culture
  • Use an in vitro model that reflects native rat islet biology with homogeneous islet size and cellular composition
  • Increase efficiency by eliminating the need to hand pick islets, with microtissues available monthly and delivered assay-ready in a non-adherent 96-well plate

Characterization Data

3D InSight™ Rat Islet Microtissues display stable viability, robust ß-cell function and optimal incretin response for more than 28 days in culture. Within each microtissue, the endocrine cells adopt a ß-cell core and the non-β-cell mantle architecture similar to native rat pancreatic islets. Uniform cytoarchitecture and functionality of rat islet microtissues enables simultaneous assessment of multiple endpoints (e.g. glucose-stimulated insulin secretion, total insulin and ATP content) in a one-islet-per-well format. The standardized islet size provides more uniform compound penetration and simplifies evaluation of changes in tissue size.

Rat Islet Microtissue Specifications

  • Guaranteed 28 days viability
  • 96-well format, 1 microtissue per well
  • Produced on demand for beta testers

Order Information

Catalog #Description
Microtissues
MT-04-001-013D InSight™ Rat Islet Microtissues
Media and Buffers*
CS-07-006-01Rat Islet Maintenance Medium, 500 mL
CS-07-006-02Rat Islet Maintenance Medium, 250 mL
CS-07-051-01Krebs-Ringer HEPES Buffer, 500 mL

* available only when purchased with 3D InSight™ Microtissues

Request Additional Resources

White Paper: An Advanced In Vitro Islet model

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Brochure: Islet Microtissues

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Find out how you can accelerate diabetes drug discovery

with a robust islet model that ensures reproducible results.

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