DILI Evaluation Kit - Insphero

Learn how to efficiently predict DILI with 3D InSight™ Human Liver Microtissues

Use our 3D InSight™ DILI Evaluation Kit to bring your bench scientists up to speed with new methods and prepare to adopt InSphero 3D microtissues as your standard preclinical model for DILI testing. This kit provides everything you need to evaluate 6 of your compounds alongside 6 reference compounds (for comparison and validation), including microtissues, pre-aliquoted reference compounds, optimized media, ATP assay reagents, and a detailed protocol. You get the full support of our 3D liver toxicology experts while you’re performing evaluation experiments, and in less than 3 weeks, you’ll have taken the first step toward integrating our microtissues into your DILI workflow.

Kit components and recommended DILI evaluation workflow

Kit Contents

  • 3D InSight™ Human Liver Microtissues (multi-donor hepatocytes, co-cultured with Kupffer cells) to test 6 of your compounds and 6 reference compounds
  • Microtissue maintenance and specialized tox testing medium – optimized for use with our liver models
  • 3D InSight™ Cytotoxicity Assay Kits, which use Promega CellTiter-Glo® technology
  • 6 Reference compounds: Ambrisentan, Sitaxsentan, Tolcapone, Entacapone, Chlorpromazine, and Ketoconazole

Order Information

Catalog #Description
KT-02-121-143D InSight™ DILI Evaluation Kit. Includes:

  • 6 plates of Human Liver Microtissues (multi-donor hepatocytes, co-culture with Kupffer cells), 96 each (MT-2-304-04)
  • 1 bottle of Human Liver Maintenance Medium – AF, 250 mL (CS-07-001a-02)
  • 1 bottle of Human Liver Maintenance Medium – TOX, 500 mL (CS-07-001-01)1
  • 2 Cytotoxicity Assay Kits, 10 mL (AK-01-001-01)
  • 3 sets of DILI reference compounds, delivered in deep-well V-bottom plate, in 7 concentrations, including DMSO as control (CP-01-201-01)

Related Applications

DILI Prediction

Services

In Vitro Toxicology

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