Animal - InSphero

Custom 3D InSight™ Animal Liver Microtissues are available only on request for research partners, who perform translational toxicology studies on a regular basis.  We offer fully tested and highly standardized monkey, dog, and rat liver toxicology models produced using species-specific primary hepatocytes and non-parenchymal liver cells.  Ideal for studying species-specific effects of liver function and toxicity these custom animal liver toxicology models can be delivered assay-ready to your lab, or used in tailored in vitro toxicology services.

  • De-risk and improve the success rate of your animal studies by pre-testing in a species-specific in vitro model that reflects in vivo biology
  • Perform chronic toxicity testing with long-term treatments in selected animal models with a culture lifetime that exceeds that of conventional 2D cell culture
  • Gain physiological relevance with an in vitro model exhibiting polarization of hepatocytes, formation of bile canaliculi, and functional cytochrome P450 activity
monkey dog rat liver spheroid models for tox testing

Animal-derived Liver Microtissues

Monkey

3D InSight™ Monkey Liver Microtissues are produced from primary cynomolgus hepatocytes and are available as monoculture or in co-culture with human Kupffer cells. This custom animal model is suitable for short- and long-term translational studies.

Catalog #Description
Microtissues
MT-02-007-013D InSight™ Monkey Liver Microtissues from primary cynomolgus hepatocytes (96x)
MT-02-007-0043D InSight™ Money Liver Microtissues from primary cynomolgus hepatocytes, co-culture with human Kupffer cells (96x)
Media
CS-07-004-01Monkey Liver Maintenance Medium, 500 mL
CS-07-004-02Monkey Liver Maintenance Medium, 250 mL

Dog

InSphero 3D InSight™ Dog Liver Microtissues are produced using primary beagle hepatocytes and are available as a monoculture or in co-culture with beagle Kupffer cells. This is an early release animal model, available to development partners only.

Catalog #Description
Microtissues
MT-02-003-013D InSight™ Dog Liver Microtissues from primary beagle hepatocytes (96x)
MT-02-003-0043D InSight™ Dog Liver Microtissues from primary beagle hepatocytes, co-culture with Kupffer cells (96x)
Media
CS-07-003-01Dog Liver Maintenance Medium, 500 mL
CS-07-003-02Dog Liver Maintenance Medium, 250 mL

Rat

3D InSight™ Rat Liver Microtissues are produced using primary Sprague-Dawley hepatocytes and are available as a monoculture or in co-culture with Sprague-Dawley Kupffer cells. This custom animal model is suitable for short-term studies only.

Catalog #Description
Microtissues
MT-02-001-013D InSight™ Rat Liver Microtissues from primary Sprague-Dawley hepatocytes, monoculture (96x)
MT-02-001-0043D InSight™ Rat Liver Microtissues from primary Sprague-Dawley hepatocytes, co-culture with Kupffer cells (96x)
Media
CS-07-002-01Rat Liver Maintenance Medium, 500 mL
CS-07-002-02Rat Liver Maintenance Medium, 250 mL

Request Additional Resources

Brochure: Solutions for Toxicology

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Publication: Proctor et al. (Arch Toxicol, 2017)

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Poster: Drug Safety Assessment with 3D InSight™ Liver Microtissues

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Find out how 3D InSight™ Liver Microtissues can provide greater

confidence in safety testing of your drugs.

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