Animal - InSphero

Custom 3D InSight™ Animal Liver Microtissues are available only on request for research partners, who perform translational toxicology studies on a regular basis.  We offer fully tested and highly standardized monkey, dog, and rat liver toxicology models produced using species-specific primary hepatocytes and non-parenchymal liver cells.  Ideal for studying species-specific effects of liver function and toxicity these custom animal liver toxicology models can be delivered assay-ready to your lab, or used in tailored in vitro toxicology services.

  • De-risk and improve the success rate of your animal studies by pre-testing in a species-specific in vitro model that reflects in vivo biology
  • Perform chronic toxicity testing with long-term treatments in selected animal models with a culture lifetime that exceeds that of conventional 2D cell culture
  • Gain physiological relevance with an in vitro model exhibiting polarization of hepatocytes, formation of bile canaliculi, and functional cytochrome P450 activity

Animal-derived Liver Microtissues

Monkey

3D InSight™ Monkey Liver Microtissues are produced from primary cynomolgus hepatocytes and are available as monoculture or in co-culture with human Kupffer cells. This custom animal model is suitable for short- and long-term translational studies.

Catalog #Description
Microtissues
MT-02-007-013D InSight™ Monkey Liver Microtissues from primary cynomolgus hepatocytes (96x)
MT-02-007-0043D InSight™ Money Liver Microtissues from primary cynomolgus hepatocytes, co-culture with human Kupffer cells (96x)
Media
CS-07-004-01Monkey Liver Maintenance Medium, 500 mL
CS-07-004-02Monkey Liver Maintenance Medium, 250 mL

Dog

InSphero 3D InSight™ Dog Liver Microtissues are produced using primary beagle hepatocytes and are available as a monoculture or in co-culture with beagle Kupffer cells. This is an early release animal model, available to development partners only.

Catalog #Description
Microtissues
MT-02-003-013D InSight™ Dog Liver Microtissues from primary beagle hepatocytes (96x)
MT-02-003-0043D InSight™ Dog Liver Microtissues from primary beagle hepatocytes, co-culture with Kupffer cells (96x)
Media
CS-07-003-01Dog Liver Maintenance Medium, 500 mL
CS-07-003-02Dog Liver Maintenance Medium, 250 mL

Rat

3D InSight™ Rat Liver Microtissues are produced using primary Sprague-Dawley hepatocytes and are available as a monoculture or in co-culture with Sprague-Dawley Kupffer cells. This custom animal model is suitable for short-term studies only.

Catalog #Description
Microtissues
MT-02-001-013D InSight™ Rat Liver Microtissues from primary Sprague-Dawley hepatocytes, monoculture (96x)
MT-02-001-0043D InSight™ Rat Liver Microtissues from primary Sprague-Dawley hepatocytes, co-culture with Kupffer cells (96x)
Media
CS-07-002-01Rat Liver Maintenance Medium, 500 mL
CS-07-002-02Rat Liver Maintenance Medium, 250 mL

Request Additional Resources

Brochure: Solutions for Toxicology

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Publication: Proctor et al. (Arch Toxicol, 2017)

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Poster: Drug Safety Assessment with 3D InSight™ Liver Microtissues

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Find out how 3D InSight™ Liver Microtissues can provide greater

confidence in safety testing of your drugs.

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