3D InSight™ Rat Liver Microtissues, Rat Liver Model | InSphero

3D InSight™ Rat Liver Microtissues are standardized, functional liver models containing primary Sprague-Dawley hepatocytes and Kupffer cells. They are delivered assay-ready for translational studies of effects of liver function and toxicity.

  • Leverage scaffold-free 3D microtissue models composed of primary rat hepatocytes and Kupffer cells
  • Predict drug-induced liver injury (DILI) in a 3D in vitro rat model that reflects in vivo species-specific toxicities (e.g., sensitivity to Acetaminophen)
  • Perform mechanistic toxicity studies in an advanced model featuring intact hepatocyte function, bile salt excretion, and inflammatory-mediated toxicity pathways

This advanced 3D rat liver model is produced using cryopreserved primary rat hepatocytes and Kupffer cells in a ratio designed to reflect the cell composition of native rat liver. Hepatocytes are polarized and form functional bile-canaliculi. The incorporation of Kupffer cells increases the sensitivity of the cells to external stimuli, such as bacteria-derived lipopolysaccharide (LPS).

Characterization Data

Rat Liver Microtissue Specifications

  • Primary Sprague-Dawley hepatocytes
  • Available as monoculture or co-culture with rat Kupffer cells
  • Ideal for short-term toxicology and translational studies
  • 96-well format, 1 microtissue per well
  • 2-week production lead time

Order Information

Catalog #Description
MT-02-001-013D InSight™ Rat Liver Microtissues from primary Sprague-Dawley hepatocytes, monoculture (96x)
MT-02-001-0043D InSight™ Rat Liver Microtissues from primary Sprague-Dawley hepatocytes, co-culture with Kupffer cells (96x)
AK-01-001-01Cytotoxicity Assay Kit (for up to 4 96-well plates)
CS-07-002-01Rat Liver Maintenance Medium, 500 mL
CS-07-002-02Rat Liver Maintenance Medium, 250 mL

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