3D InSight™ Assay-ready Tumor Microtissues, Tumor Models | InSphero

Gain greater translational insights with pre-qualified tumor-stromal co-cultures

InSphero assay-ready 3D InSight™ Tumor Microtissues are designed to simplify and accelerate oncology drug efficacy testing. Using the 3D Select™ Process, our oncology experts have identified optimal culture conditions for large-scale, reproducible production of 3D spheroid models that better reflect complex tumor biology.

  • Leverage physiologically relevant 3D tumor co-cultures composed of tumor and stromal components — with no artificial matrices
  • Assess single agent or combinatorial efficacy of small molecule, biological, ADC, or immunomodulatory drugs using 3D optimized endpoints
  • Test in ISO 9001:2015 quality controlled pre-validated models that optimize your staff resources and ensure robuts, reproducible results

Scaffold-free tumor-stromal co-cultures display cell-line and culture condition dependent cellular arrangements. In A549 and SKOV-3 co-culture models, fibroblasts (brown FAP staining) are integrated within the tumor cells. In the HCT-116 model, fibroblasts organize themselves in a central core that is surrounded by tumor cells.

Assay-Ready Tumor Microtissue Specifications

  • Viability model dependent
  • 96-well format, 1 tumor microtissue/well
  • Produced on demand; production schedule dependent on cell line

We can produce monoculture or co-culture tumor microtissues using the cell lines and stromal cells listed here.  If you don’t see the cell line you need, we can build a custom model for you.

Order Information

Tumor Microtissues (co-culture with stromal cells)

Validated Tumor Cell Lines

TumorCell Line
Breast
  • MCF-7
  • T47D
  • MDA-MB-231
  • MDA-MB-361
  • MDI-MB-468
  • BT474
Colorectal
  • DLD-1
  • LS174T
  • HCT-116
  • LoVo
Stomach
  • NCI-N87
Lung
  • A549
  • H292
  • NCI-H460
  • NCI-H2170
  • NCI-H1975
  • HCC-827
Kidney
  • A498
  • 786-O
  • COLO-205
Prostate
  • 22RV1
  • DU-145
  • LnCap
  • PC-3
Brain
  • SNB-19
  • LN-18
Pancreas
  • PANC-1
Ovarian
  • A2780
  • SKOV-3
  • HEY
Liver
  • HEP-G2
  • Huh-7
CervicalC33-A

Stromal Cells

Stromal CellSpecies
NhDFHuman
NIH3T3Mouse
SV-80Human
CAFHuman

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Brochure: Tumor Microtissues

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Poster: 3D InSight™ Oncology Drug Discovery Platform

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