Standardized tumor model development using the InSphero 3D Select™ Process
We can work with you to develop a custom tumor model to fit your project using our 3D Select™ Process and patented InSphero scaffold-free assay platforms.
Select or provide a tumor cell line or PDX model, and we’ll optimize conditions for organoid formation to develop monoculture or co-culture (with fibroblasts) models to fit your needs.
Once established, the custom tumor model can be used in 3D InSight™ Oncology Services or delivered assay-ready for use in your lab.
Custom Tumor Model Specifications
Custom Tumor Model Service Description
-
- Feasibility and optimization of spheroid formation
- Size-based growth kinetics over 10 days in culture
- ATP after tissue formation and 10 days in culture
- Histology at day 4 and 10 (H&E plus 3 markers)
- Full written report and consultation
Custom Tumor Model specifications
- Viability model-dependent
- 96-well format, 1 microtissue per well
- Produced on demand; production schedule dependent on cell line or PDX material
Order Information
Supply your own cell line, or select from one of the many established tumor cell lines available for custom model development.
| Tumor Type | Cell Line | Fluorescence | 3D Monoculture |
|---|---|---|---|
| Breast | MCF-7 TD-47D* MDA-MB-231 MDA-MB-361* BT474 |
— RFP RFP RFP — |
no yes no yes yes |
| Colorectal | HT-29 DLD-1* LS174T* HCT-116* LoVo |
— — GFP GFP — |
yes yes yes yes yes |
| Stomach | NCI-N87* | GFP | yes |
| Lung | A549* H292 NCI-H460 NCI-H2170 NCI-H1975 NCC-827 |
GFP — — — — — |
yes yes yes yes yes yes |
| Kidney | A498* 786-O* COLO-205 |
— — — |
yes yes no |
| Prostate | 22RV1 DU-145* LnCap PC-3 |
— — — — |
yes yes yes no |
| Brain | SNB-19 LN-18 |
— GFP |
yes yes |
| Pancreas | PANC-1* | GFP | no |
| Ovarian | A2780 SKOV-3 HEY* |
— — GFP |
yes no yes |
| Liver | HepG2* | — | yes |
Certified Applications
Efficacy Testing
- Single Drug Testing
- Combinatorial Drug Testing
- Tumor Relapse
Immuno-oncology
- Infiltration
- Immune-mediated Tumor Cell Killing
- Antibody Penetration
