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- Liver Safety
Assessment of nanomaterial-induced hepatotoxicity using a 3D human primary multi-cellular microtissue exposed repeatedly over 21 days - the suitability of the in vitro system as an in vivo surrogate
- Publication
- Liver Safety
Microplastic-induced hepatic adverse effects evaluated in advanced quadruple cell human primary models following three weeks of repeated exposure
- Publication
- Liver Safety
Translational framework linking perfluoroheptanoic acid (PFHpA) exposure to metabolic dysfunction associated steatotic liver disease in adolescents
- Publication
- Liver Safety
Nucleophosmin 1 induction is an early event in a Phenobarbital induced proliferation response in rat but not human liver 3D microtissues
- Publication
- Liver Safety
Cross-species comparison of CAR-mediated procarcinogenic key events in a 3D liver microtissue model
- Publication
- Liver Safety
Assessing the impact of perfluoroalkyl substances on liver health: a comprehensive study using multi-donor human liver spheroids
- Publication
- Liver Safety
New approach methodologies (NAMs) for drug-induced liver injury (DILI): Where are we now?
- Publication
- Liver Safety
Toxicity of ubiquitous tire rubber antiozonant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its transformation product 6PPD-quinone (6PPD-Q) in primary human hepatocytes and liver spheroids
- Publication
- 3D Cell Culture Technology, Liver Disease, Liver Safety
Sweet and sticky: increased cell adhesion through click-mediated functionalization of regenerative liver progenitor cells
- Publication
- Liver Safety
TAK-994 mechanistic investigation into drug-induced liver injury
- Publication
- Liver Safety
Transcriptomic analysis in liver spheroids identifies a dog-specific mechanism of hepatotoxicity for amcenestrant
- Publication
- Liver Safety
Deciphering per- and polyfluoroalkyl substances mode of action: comparative gene expression analysis in human liver spheroids
- Publication
- Liver Safety
Multi-organ model assessment of neurotoxicity following exposure of liver spheroids to drugs
- Publication
- Liver Safety
InSphero & FDA's NCTR Peer-reviewed Paper | Physiological liver microtissue 384-well microplate system for preclinical hepatotoxicity assessment of therapeutic small molecule drugs
- Publication
- Liver Safety
Expression Analysis of Exosomal MicroRNAs in Chlorpromazine Treated Human Hepatic Spheroids: A Promising Tool for Novel Drug-Induced Liver Injury Biomarker Discovery
- Publication
- Liver Safety
Preclinical Characterization and Phase I Trial Results of INBRX-109, A Third-Generation, Recombinant, Humanized, Death Receptor 5 Agonist Antibody, in Chondrosarcoma
- Publication
- Liver Safety
High-throughput transcriptomic analysis of human primary hepatocyte spheroids exposed to per- and polyfluoroalkyl substances (PFAS) as a platform for relative potency characterization
- Publication
- Liver Safety
Translational Safety: The Next Frontier for 3D In Vitro Liver Toxicity Testing
- Publication
- Liver Safety
Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations
- Publication
- Liver Safety
The importance of inter-individual Kupffer cell variability in the governance of hepatic toxicity in a 3D primary human liver microtissue model
- Publication
- Liver Safety
Transcriptomic, Proteomic, and Functional Long-term Characterization of Multicellular Three-Dimensional Human Liver Microtissues
- Publication
- Liver Safety
Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury
- Publication
- Liver Safety
Mechanisms of hepatotoxicity associated with the monocyclic β-lactam antibiotic BAL30072
- Publication
- Liver Safety
Hepatic 3D spheroid models for the detection and study of compounds with cholestatic liability
- Publication
- Liver Safety
Extending the limits of quantitative proteome profiling with data-independent acquisition and application to acetaminophen treated 3D liver microtissues
- Publication
- Liver Safety
Differential basolateral-apical distribution of scavenger receptor, class B, type I in cultured cells and the liver
- Publication
- Liver Safety
Hepatic toxicology following single and multiple exposure of nanomaterials utilising a novel primary human 3D liver microtissue model
- Publication
- Liver Safety
State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology
- Publication
- Liver Safety
Characterization of a Rat Multi-Cell Type 3D-Liver Microtissue System
- Publication
- Liver Safety