Multiply the predictive power of 3D InSight™ Microtissues using InSphero's Microphysiological System
InSphero engineered the Akura™ Flow microphysiological system to be compatible with our complete portfolio of 3D InSight™ organoids, opening the door to a nearly unlimited variety of pre-clinical efficacy and toxicity testing applications in a multi-tissue, microfluidic assay format.
From early prototypes conceived as part of the EU Body-on-a-Chip Project, our goal has been to provide a pharma-ready microfluidic device for integrating advanced 3D microtissues in multi-tissue and organ-on-a-chip networks in our microphysiological system.
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The Akura™ Flow microphysiological system provides experimental continuity between single- and multi-tissue testing applications, enabling the seamless integration and optimal utilization of standardized 3D models from a single provider.
The complete microphysiological system includes pre-qualified 3D InSight™ Microtissues, media, assays, and tilting-based flow control.
- Minimize cell, medium, and compound use in a miniaturized 10-microtissue configuration that increases cell-to-media volume ratio up to 10-fold
- Leverage maximum physiological complexity while minimizing operational complexity with an automation-compatible, tubeless, tilting-based medium perfusion system to interconnect assay-ready advanced 3D models
- Compare numerous conditions in parallel on one plate allowing for the first-time throughput-compatible testing with a truly scalable microphysiological system not limited in the number of statistical replicates it can accommodate
- Rely on a diverse array of experimental endpoints ranging from cell-based and biochemical assays to on-chip high-content imaging, with flexible liquid sampling and non-disruptive microtissue retrieval
Global Recognition for the EU Body-on-a-Chip Project
- European Parliament showcased EU Body on a Chip Project success story in 2018 EU Future and Emerging Technologies (FET) Program.
- Akura™ Flow selected as one of the top ten finalists for the SLAS2018 Innovation Award
- Scientist Receives 3Rs Award for Microtissue-based Body on a Chip System [Press Release]
- InSphero Publication Honored for Potential to Reduce Use of Research Animals [Press Release]
- The EU Body on a Chip Project honored by the Seventh European Union Framework Programe (FP7) in the Achievements of FP7 – examples that make us proud booklet. Read more …
- European Commission article summarizing BoC Project
- European Commission Blog Post by InSphero CTO Dr. Jens M. Kelm