Diabetes Drug Testing | InSphero

Assess islet function and efficacy of diabetes drugs with a customizable study plan

The homogeneous cellular composition, organotypic function, and long-term viability of 3D InSight™ Islet Microtissues make them an ideal model for studying pancreatic islet function, regeneration, and preservation in healthy and disease states.  Our services team will work with you to design and implement a custom study package tailored to your needs.

  • Choose your islet model (human or rat)
  • Select your desired endpoints from the menu below
  • Work with our services team to customize your study plan
ServicesEndPoints
β-cell function
  • Glucose-stimulated and basal insulin secretion
  • Insulin content
α-cell function
  • Glucose-regulated glucagon secretion
  • Glucagon content
Islet viability and apoptosis
  • Islet size
  • ATP content
  • Caspase 3/7 activity
β-cell proliferation
  • EdU and β-cell marker costaining
β-cell function
  • Glucose-stimulated and basal insulin secretion
  • Insulin content
Type 2 diabetes modeling
  • β-cell function and islet viability under metabolic stress
Type 1 diabetes modeling
  • β-cell function and islet viability under immune attack or inflammation
Pancreatic islet toxicity
  • β-cell function and islet viability under compound-induced stress

Find out how you can accelerate diabetes drug

discovery with 3D InSight™ services.

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Brochure: Human Islet Microtissues

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White Paper: An Advanced In Vitro Islet Model

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