Custom Mechanistic & Investigative Studies | InSphero

Investigate mechanisms of liver injury with a study tailored to your needs

Leverage our scientific staff and mechanistically accurate 3D InSight™ Liver Microtissues to dig deeper into mechanisms of hepatotoxicity.

  • Choose your dosing scheme: short term (3-7 days) or long term (14-28 days)
  • Select your desired endpoints
  • Work with our services team to design a custom study plan that we’ll conduct for you using the  appropriate 3D optimized assays

Multiparametric endpoint examples

Toxicity mechanismEndpoints
  • Hepatotoxicity
  • ATP-content
  • α-GST (released/intracellular)
  • Albumin secretion
  • LDH release
  • Kupffer-cell function/toxicity
  • IL-6 production
  • TNF-α production
  • Mitochondrial impairment
  • Lactate secretion
  • Mitochondrial activity
  • Reactive metabolites
  • Lower GSH content
  • Metabolic competence
  • Cytochrome activation/induction
  • Apoptosis
  • Caspase 3/7 activation
  • Steatosis, phospholipidosis
  • Lipid accumulation
  • Cholestasis
  • Efflux transporter inhibition
  • Cancerogenicity
  • DNA-synthesis
  • Unbiased discovery of MOA
  • Transcriptomics
  • Proteomics

Microtissues and Kits

Liver

Request Additional Resources

Brochure: Solutions for Toxicology

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Poster: Drug Safety Assessment with 3D InSight™ Liver Microtissues

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Find out how you can investigate mechanistic tox

with greater confidence.

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