3D InSight™ Cancer Drug Efficacy Testing

Biochemical and phenotypic assessment of drug potency and efficacy testing

Drug efficacy testing for your compounds or biologics of interest to assess their potency (EC₅₀) and efficacy (maximum response) on tumor organoids using 3D-optimized biochemical (ATP) and phenotypic (size) endpoints.

Efficacy testing service protocol

Choose a 3D InSight™ Tumor model and supply at least 2 test compounds
Choose controls (e.g., Staurosporine, MEK162, Ipatasertib, Sorafenib/Sunitinib, DMSO, etc.)
Produce a 9-point dose response in quadruplicate
Perform an 11-day efficacy testing assay with dosing at days 0, 4, and 7

Efficacy Testing Characterization Data

Evaluate anti-tumor efficacy in physiologically relevant 3D models. Receive ATP-based dose-response curve and dose-dependent size-based growth kinetics.

Leverage non-disruptive, continuous size assessment to monitor tumor response over time, preserving samples for optional customized endpoints. Potency and efficacy of the MEK inhibitor Binimetinib (MEK-162) in HepG2 spheroids.

Efficacy Testing at a Glance

Download our brochure for details on the standard protocol.

Drug Efficacy Testing Service Report includes

ATP-based dose-response curve at day 11
Size-based dose-response curve and growth kinetics over time
Efficacy testing (IC₅₀) values

Catalog #	Description
SP-01-041-02	3D InSight™ Efficacy Testing Service (2 or more compounds, 2 controls, 1 model)

Drug Efficacy Testing - Related Services

Oncology Drug Discovery

3D InSight™ Spheroids

Tumor

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3D InSight™ Efficacy Testing

Biochemical and phenotypic assessment of drug potency and efficacy testing

Efficacy testing service protocol

Efficacy Testing Characterization Data

Efficacy Testing at a Glance

Drug Efficacy Testing Service Report includes

Drug Efficacy Testing - Related Services

Oncology Drug Discovery

3D InSight™ Spheroids

Tumor

Request Additional Resources for our Drug Efficacy Testing Services

Brochure: Oncology Services

Download PDF Form

Poster: 3D InSight™ Oncology Drug Discovery Platform

Download PDF Form

Brochure: Immuno-Oncology Services

Download PDF Form

Find out how you can screen new cancer drugs more efficiently

with services using our advanced 3D tumor models.

Get Started – Oncology