3D InSight™ Islet Biology Platform

Your complete end-to-end solution portfolio for the study of islet function, β-cell regeneration and β-cell preservation in physiologically relevant disease models

We engineer 3D InSight™ Islet Microtissues to address the major issues associated with isolated native islets, such as heterogeneity, variable purity and limited ex vivo life span. Through scaffold-free and high-throughput reaggregation of dispersed fresh or cryopreserved primary islet cells, we generate uniform and standardized pseudoislets that mimic the complex architecture and function of human pancreatic islets. The stable functionality and viability (>28-days) of islet microtissues make them ideal for longitudinal studies of pancreatic endocrine cell function, identity, survival, proliferation and transdifferentiation under type 1 or type 2 diabetes-relevant stress conditions.

By selecting our streamlined islet biology and disease modelling services - or by incorporating our standardized 3D islet models and assays into your existing workflows - you will benefit from unmatched robustness, throughput, and physiological relevance in your diabetes research.

Why Islet Biology with InSphero?

Our mission is to support you in advancing your diabetes research, through our market-leading products and services
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Rely on the new gold standard for human islet research

Uniform, functionally robust and long-lived human islet microtissues are the only pre-qualified and assay-ready islet model on the market

Leverage readily available islets from cryopreserved donor cells

Can't find the donor with the right characteristics or want to conduct additional tests with islets from the same donor? Request a production from our human islet cell cryo-bank.

Obtain tailored solutions from our comprehensive assay portfolio

A versatile solution platform of standardized disease models and 3D-cell culture compatible end-point assays enable robust, reliable and rapid data generation

Gain expert support in design and execution

Our impact is measured by the success of your research. We expand your team by bringing over a decade of research experience with islet microtissues.

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Our Approach

Plan with diligence

We start by discussing your specific goals and challenges to select the best islet and disease models for your needs.

Execute with precision

Next, we run standardized assays or develop novel solutions tailored to your needs. These assays can be performed at InSphero or integrated into your pre-existing workflows.

Conclude with confidence

We help you achieve reproducible and high-quality results that will drive meaningful conclusions.

Propel your research

By assuming the burden of in vitro modeling, we enable you to refocus valuable time on accelerating your research program.

Services

3D InSight™ Human Beta Cell Proliferation Service

Products

3D InSight™ Human Islet Microtissues

“InSphero islets have been invaluable for our studies of the effects of chronic hyperglycaemia, and we were delighted to find that cryo-preserved islets behaved like fresh islets as this gave us more experimental options. The service work InSphero did for us was also excellent.”

Dame Frances Ashcroft, DBE, FRS, FMEDSCI Professor of Physiology
University of Oxford

"Addressing complex diseases requires the rare combination of pioneering innovation and biomedical expertise. As our discovery partner, InSphero gives us immediate access to new 3D cell culture in vitro technologies, such as organ-on-a-chip systems, that provide deep mechanistic insights into complex diseases. They have become part of our research team, committed to helping us find a cure for Type 1 Diabetes.”

Matthias von Herrath, MD, Vice President and Senior Medical Officer
Novo Nordisk

“For us, InSphero islets represent the new gold standard for studies on human pancreatic islets. They are an extremely valuable and reproducible resource for the islet research community.”

Patrik Rorsman, PhD, FRS, FMEDSCI, Professor of Diabetic Medicine
University of Oxford
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