We engineer 3D InSight™ Islet Microtissues to address the major issues associated with isolated native islets, such as heterogeneity, variable purity and limited ex vivo life span. Through scaffold-free and high-throughput reaggregation of dispersed fresh or cryopreserved primary islet cells, we generate uniform and standardized pseudoislets that mimic the complex architecture and function of human pancreatic islets. The stable functionality and viability (>28-days) of islet microtissues make them ideal for longitudinal studies of pancreatic endocrine cell function, identity, survival, proliferation and transdifferentiation under type 1 or type 2 diabetes-relevant stress conditions.
By selecting our streamlined islet biology and disease modelling services – or by incorporating our standardized 3D islet models and assays into your existing workflows – you will benefit from unmatched robustness, throughput, and physiological relevance in your diabetes research.
Drug efficacy and toxicity
• α-cell and β-cell function
• Cell viability
Assessment of β– and non-β-cell proliferation
Type 1 diabetes models
• Cytokine-induced islet injury
• Islet / PBMC co-culture
• Islet / proinsulin-specific cytotoxic
T cell co-culture
• Treg Efficacy
Type 2 diabetes models
• Glucotoxicity
• Glucolipotoxicity
• Lipotoxicity
Modification of gene expression
(Viral transduction)
• Target Validation
• Transdifferentiation
Uniform, functionally robust and long-lived human islet microtissues are the only pre-qualified and assay-ready islet model on the market
Can’t find the donor with the right characteristics or want to conduct additional tests with islets from the same donor? Request a production from our human islet cell cryo-bank.
A versatile solution platform of standardized disease models and 3D-cell culture compatible end-point assays enable robust, reliable and rapid data generation
Our impact is measured by the success of your research. We expand your team by bringing over a decade of research experience with islet microtissues.
We start by discussing your specific goals and challenges to select the best islet and disease models for your needs.
Next, we run standardized assays or develop novel solutions tailored to your needs. These assays can be performed at InSphero or integrated into your pre-existing workflows.
We help you achieve reproducible and high-quality results that will drive meaningful conclusions.
“Addressing complex diseases requires the rare combination of pioneering innovation and biomedical expertise. As our discovery partner, InSphero gives us immediate access to new 3D cell culture in vitro technologies, such as organ-on-a-chip systems, that provide deep mechanistic insights into complex diseases. They have become part of our research team, committed to helping us find a cure for Type 1 Diabetes.”
“For us, InSphero islets represent the new gold standard for studies on human pancreatic islets. They are an extremely valuable and reproducible resource for the islet research community.”
“InSphero islets have been invaluable for our studies of the effects of chronic hyperglycaemia, and we were delighted to find that cryo-preserved islets behaved like fresh islets as this gave us more experimental options. The service work InSphero did for us was also excellent.”
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