In this webinar from the SOT 2020 program, InSphero CSO and Toxicologist Prof. Armin Wolf and Dr. Monika Kijanska introduce a framework for mechanistic toxicology investigations, based on a suite of causality assays developed for our 3D InSight™ Liver Toxicology Platform. Armin and Monika discuss how to design experimental programs that help validate relationships between events that trigger toxic responses and identify adverse outcome pathways implicated in drug-induced liver injury (DILI), and present example data generated using our liver toxicology platform.
You will learn:
- How one simple, proven causality assay applied using different models at different time points can help tease out mechanisms of DILI
- How to tune and adapt 3D-optimized causality assays for a wide range of pathways using specific pathway modulators for DILI-specific mechanistic investigations and mechanism based screening
- Advantages of using a scalable, robust, and versatile 3D in vitro platform for liver toxicology studies