Blog

Antisense oligonucleotides (ASOs) offer therapeutic avenues for diseases that are currently unmet by alternative therapeutic modalities. However, the development of therapeutic ASOs is often hampered by hepatotoxicity. In this blog, we explore why 3D human liver microtissues are becoming an indispensable tool for de-risking ASO drug candidates and for reducing attrition in late-stage drug development. 

Toxicological studies show that drugs can alter mitochondrial functions, potentially resulting in a deleterious range of toxic reactions from the induction of micro- and macrovesicular steatosis to lactic acidosis. These clinical manifestations are the consequence of drugs interfering with four main mitochondrial functions or constituents: aerobic respiration, beta-oxidation, and mitochondrial DNA homeostasis.

Ensuring that spheroids are intact during liquid exchange is not fun and certainly not easy. That’s why we developed our Akura™ Microplates with a special feature to make your life much easier: The SureXchange™ well design enables optimal protection of the spheroids in a cavity at the bottom of the well during liquid exchange.

What else do you need to know to prevent tissue loss? Our Senior Product Manager, Dr. Frauke Greve, asked InSphero's 3D in vitro experts about their tips and tricks.

Drug-induced liver injury (DILI) remains a significant challenge in the development of safe and effective pharmaceuticals. The complexity of DILI assessment in the preclinical phase is compounded by the need for solutions that balance cost, throughput, and turnaround time without compromising sensitivity, specificity, reproducibility, and robustness. This blog delves into the trade-offs between complex, microfluidic DILI assessment methods and more scalable, robust solutions, mature enough for industrial application.

To 2D or 3D Cell Culture - that is no longer the question.
It has become evident that 3D cell-based assays outmatch traditional 2D monolayer cell cultures, as they enable cells to grow into three-dimensional structures that more closely mimic the architecture and interactions found in tissues and organs. Discover the 3 critical aspects that set the industry-ready 3D in vitro models, apart from the rest of the available solutions.