3D InSightâ„¢ | 3D In Vitro Oncology and Immunology Platform

Uncover valuable insights into mechanisms of action and the effect of multiple cell types in Oncology and Immunology by using our physiologically relevant and scalable 3D Human tumor models.

NEW: 3D InSightâ„¢ Patient-derived Primary Tumor Spheroid Platform

Transform your therapeutic development by incorporating patient heterogeneity early on in your drug discovery platform

Our 3D InSightâ„¢ Patient-derived Primary Tumor Spheroid Platform revolutionizes preclinical oncology by accurately mirroring patient-specific genomic diversity, complexity of the tumor microenvironment and clinically relevant drug responsiveness - transforming in vitro modeling into predictive insights that align seamlessly with in vivo patient outcomes.

Built on the foundation of InSphero’s expertise with primary tissue models and scalable platforms, these models offer predictive, robust, and reproducible results for informed decision-making.

Why it matters?

All preclinical models, from cell lines to patient-derived xenografts (PDXs) serve a purpose in the spectrum of early discovery. However, they all fail to capture the intra- and inter-tumor complexity of tumors in vivo. Our patient-derived primary tumor spheroids overcome these limitations by:

  • Maintaining the original composition of the tumor, including epithelial immune and stromal components
  • Reflecting patient-specific heterogeneity and therapeutic responses
  • Supporting robust, high-throughput drug screening in Akuraâ„¢ 96- and 384-well plate formats
  •  

Unlock the full potential of your oncology research

Physiological and Biological Relevance

3D InSightâ„¢ Patient-derived tumor spheroid - Physiological

Patient-derived tumor spheroids retain the architecture and complexity of the original tumor tissue, as confirmed by immunohistochemistry (IHC) for all resident cell populations. This ensures physiological and biological relevance for drug screening applications.    

Industry-Grade
Scalability

Scalable patient-derived model

Therapeutic testing across multiple patient-derived tumor spheroids using automation-compatible Akuraâ„¢ 96 and 384 well plates with high-dimensional, high throughput readouts.

Proven
Reproducibility

3D InSightâ„¢ Patient-derived tumor spheroid - Reproducible

Consistent composition and size of Patient-derived Primary tumor spheroids enable robust and reproducible therapeutic screening across oncology applications.

Bring confidence to your oncology pipeline with 3D in vitro models that reflect real patient biology

3D Tumor Models for Advanced 3D In Vitro Oncology and Immunology Research

Conventional, 2D-monolayer cell line-derived tumor models produce generic oncology readouts for viability. The outdated flat biology, which is not representative of tumor and patient heterogeneity is unable to fully capture the unpredictable progression of a complex disease like cancer.

Our 3D InSight™ Oncology platform provides human-derived 3D tumor models that enable you to study cellular interaction in a 3D environment. Our technology enhances the ability to assess various phenotypic characteristics that can accurately predict different aspects of in vivo biology.

Our scalable, reliable and reproducible 3D tumor models allow you to study intracellular interactions and the effect of the tumor micro environment  (TME) on therapeutic resistance and susceptibility. Our ability to multiplex imaging, biochemical and morphological read outs ensure that you maximize the information you get out of a  single tumor spheroid in the context of its TME. Our platform is compatible with many therapeutic modalities including but not limited to small molecules, biologics, protein therapeutics and siRNAs. Each modality is validated on the 3D InSight ™ tumor spheroid platform for biological and technical activity. 

Why 3D In Vitro Oncology and Immunology with InSphero?

Unlock the full potential of your oncology research with innovative 3D tumor models, reflecting the complexity of the disease, while preserving high reproducibility and scalability. Make early-stage decisions for breakthrough therapies in Oncology and Immunology.

Human 3D tumor models are the future of cancer research

InSphero has pioneered the gold standard for liver toxicology with its 3D InSightâ„¢ Liver Model. Based on it, our disease models are leveraging the uniformity, robustness, and ease of use that accelerates your research.

Scalable, industry-ready 3D in vitro tumor spheroids

Enhance your drug investigation by using our scalable 3D InSightâ„¢ Oncology & Immunology platform, reproducing the complex tumor micro-environment.

Monitoring the immune component in cancer biology

Measuring various facets of the tumor-immune interaction in a scalable 3D in vitro model is key to understanding therapeutic resistance, especially for IO indications.

Make early-stage go/no-go decisions

Incorporating physiologically relevant, 3D cell culture oncology models at the beginning of the hit-to-lead process results in less attrition, enabling informed early-staged decisions.

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Our Approach in 3D In Vitro Oncology and Immunology

Reliable and fast hazard identification in 3D in vitro liver safety assessment

Target Identification and Validation

Identification and validation of potential drug targets in a physiologically relevant context
An icon showcasing the 3D tumor model in a well for Oncology and Immunology research

Modeling tumor heterogeneity and patient diversity

Use genomically characterized patient-derived xenograft (PDX) models to reflect the heterogeneity seen in patients

High throughput screening

High throughput screening with multiplexed endpoints provides rich datasets that allow for rational decision-making

Modular platform

Build tumor models with differing layers of complexity and throughput to interrogate different biological questions for therapeutic compounds in question

Services

3D InSightâ„¢ Therapeutic Modality Screening
3D InSightâ„¢ Immuno-Oncology Screening

Products

Akuraâ„¢ Immune Flow Organ-on-Chip Platform
ARCTisâ„¢ Human Tumor - Cryopreserved 3D Tumor Models
ARCTisâ„¢ Human Tumor - Cryopreserved 3D Tumor Models
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