Resources

Early Detection of Hepatotoxic Compounds in Drug Development: Leveraging the Potential of Human Liver Microtissues for Predictive Screening

Automated Tumor Spheroid Handling on the epMotion® 5073t using InSphero Akura™ Plates

Digital pathology with artificial intelligence analysis provides insight to the efficacy of anti-fibrotic compounds in human 3D MASH model

Assessment of cancer metastatic potential in Akura™ Immune Flow Platform

Species-Specific Liver Microtissues: A Set of Micro-physiological Systems to Assess Translational Hepatotoxicity in Drug Development

3D InSight™ Islet Biology Platform

Akura™ Immune Flow Overview

The 3D DILI Model of Success – from Biological Relevance to Industry Application

Scalable 3D Cell Culture-based Retinal Fibrosis Model for Efficacy Testing

Assessing anti-tumor efficacy of tumor-dendritic cell reprogramming using immuno-competent 3D tumor microtissue models

Advancing Oncology and Immune-Oncology Therapeutic Development Using 3D Tumor Spheroids

Digital pathology with artificial intelligence analysis provides insight to the efficacy of anti-fibrotic compounds in human 3D MASH model

Screening and comparison of current clinical candidates in MASH using human liver spheroids

Extending the choice of ULA plates for primary 3D human liver spheroid formation and experimentation with the Akura™ Spheroid Microplates

Deciphering Metabolic Cross-Talk: Insights into Liver-Islet Interactions with human Microtissues and scalable Microphysiological Systems

3D InSight™ Human Islet Microtissues

Enhancing Scalability and Quality of 3D In Vitro Cell Models Production through Automation

Assessment of immune cell infiltration and cancer metastatic potential in Akura™ Immune Flow Chip - A microfluidic 3D spheroid system

3D InSight™ Tumor Spheroids: Balancing Physiological Relevance with Scalability and Reliability in Oncology Therapeutic Testing

Human 3D InSight™ Tumor Spheroids: Reliable and Scalable In Vitro System to Model Immune Responses and Evaluate Cancer Immunotherapeutics

Innovation in 3D In Vitro Oncology: Novel Insights and Reproducible Results with Data-Driven ADC Penetration Study

New microplate platform with cryopreserved 3D tumor spheroids for faster and convenient pre-clinical testing

Mitigation of liver toxicity effects of bispecific T cell engagers in immune-competent liver-tumor co-culturing high-throughput platform

Initial evaluation of the use of human liver microtissues for the hepatotoxicity assessment of antisense oligonucleotides

On the relevance of human liver microtissues for the detection of hepatoxic drugs early in the drug development process

Patient-derived steatotic hepatocytes reveal non-cell autonomous inflammation and fibrogenic effects in multicellular liver spheroids

InSphero MASH CALL Flyer

ARCTis™ Cryo Tissues - How to prepare plate

Preclinical Characterization and Phase I Trial Results of INBRX-109, A Third-Generation, Recombinant, Humanized, Death Receptor 5 Agonist Antibody, in Chondrosarcoma

RNA Seq Analysis - Sample EXTENDED Report

RNA Seq Analysis - Sample GENE MINING Report

RNA Seq Analysis - Sample BASIC Report

InSphero MASH CALL Initiative Overview

A 3D primary human cell-based in vitro model of non-alcoholic steatohepatitis for efficacy testing of clinical drug candidates

Heterologous Protein Production Capacity of Mammalian Cells in 2D and 3D cultures

Scaffold-free cell delivery for use in regenerative medicine

Microscale tissue engineering using gravity-enforced cell assembly

3D Cell Culture for Compound De-Risking

Patient-derived tumor spheroid cultures as a promising tool to assist personalized therapeutic decisions in breast cancer

A Novel Concept for Scaffold-Free Vessel Tissue Engineering: Self-Assembly of Microtissue Building Blocks

Predicting Metabolism-Related Drug-Drug Interactions with Organ-on-a-Chip Technology

Particulate and drug-induced toxicity assessed in novel quadruple cell human primary hepatic disease models of steatosis and pre-fibrotic NASH

Scalable 3D Cell Culture Technologies Engineered for Physiological InSight

Artificial Intelligence in Digital Pathology: Quantification of Fibrosis in Human 3D NASH Model

InSphero and Hamilton collaborate to improve the production and handling of spheroids

Human 3D in vitro NASH model for efficacy testing of clinical drug candidates

Assessing the predictive response of a simple and sensitive blood-based biomarker between estrogen-negative solid tumors

InSphero Islet Biology - picking islets for diabetes research

InFloat™ Shipping Solution for 3D InSight™ Assay-ready Microtissues

miR-149 suppresses breast cancer metastasis by blocking paracrine interactions with macrophages

How we applied InSphero technology to create a human liver NASH model

3D InSight™ Human Islet Microtissues as an in vitro and an in vivo model system for Type 1 and Type 2 Diabetes

Modeling NAFLD: From Steatosis to NASH and Fibrosis

Formation and optimization of three-dimensional organoids generated from urine-derived stem cells for renal function in vitro

Extra Cellular Matrix Deposition and Assembly in Dermis Spheroids

Redefining NASH Drug Discovery: A New Approach to Complex Disease Modeling

A Novel, High-Resolution Perifusion Platform for Studying Insulin Release Dynamics of Single Human Pancreatic Islets

Optimizing High-Content Imaging of 3D Models for Drug Discovery

Implementing High Resolution, High Content Image Analysis with Multicellular 3D Spheroid Models

A Novel Framework for Teasing Out Mechanisms of DILI

Optimizing 3D Spheroid Models for Efficient Drug-Induced Liver Injury Screening

How to Evaluate Preclinical and Clinical DILI

Novel Lipidomic-based Approach to Liver Drug Safety

Activated Cardiac Fibroblasts Control Contraction of Human Fibrotic Cardiac Microtissues by a -Adrenoreceptor-Dependent Mechanism

Manual medium exchange under 2 minutes with InSphero Akura™ 96 Spheroid Microplate

Akura™ Flow Organ-on-a-Chip Technology

Three-dimensional renal organoids from whole kidney cells: generation, optimization, and potential application in nephrotoxicology in vitro

Generation of uniform liver spheroids from human pluripotent stem cells for imaging-based drug toxicity analysis

In vitro cell culture of patient derived malignant pleural and peritoneal effusions for personalised drug screening

Hepatic toxicology following single and multiple exposure of nanomaterials utilising a novel primary human 3D liver microtissue model

Differential basolateral-apical distribution of scavenger receptor, class B, type I in cultured cells and the liver

State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology

Cell culture: A better brew

Multi-cell type human liver microtissues for hepatotoxicity testing

A Framework for Optimizing High-Content Imaging of 3D Models for Drug Discovery

A 3D co-culture microtissue model of the human placenta for nanotoxicity assessment

Integrating Microtissues in Nanofiber Scaffolds for Regenerative Nanomedicine

An in vitro osteosarcoma 3D microtissue model for drug development

A 3D-microtissue-based phenotypic screening of radiation resistant tumor cells with synchronized chemotherapeutic treatment

Extending the limits of quantitative proteome profiling with data-independent acquisition and application to acetaminophen treated 3D liver microtissues

High-throughput imaging: Focusing in on drug discovery in 3D

A High-Throughput–Compatible 3D Microtissue Co-culture System for Phenotypic RNAi Screening Applications

Development of an innovative 3D cell culture system to study tumour–stroma interactions in non-small cell lung cancer cells

Additive impact of HER2-/PTK6-RNAi on interactions with HER3 or IGF-1R leads to reduced breast cancer progression in vivo

Three-dimensional microtissues essentially contribute to preclinical validations of therapeutic targets in breast cancer

Evaluation of assays for drug efficacy in a three-dimensional model of the lung

Characterization of a Rat Multi-Cell Type 3D-Liver Microtissue System

3D cell culture systems modeling tumor growth determinants in cancer target discovery

Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations

High-throughput transcriptomic analysis of human primary hepatocyte spheroids exposed to per- and polyfluoroalkyl substances (PFAS) as a platform for relative potency characterization

Characterization and Drug Sensitivity Testing of HTS-Compatible Cancer Microtissues

Multiplexed Drug Assessment in 3D. Combining Luminescence and Fluorescence Genetic Reporters to Assess Drug Effects

Translational Safety: The Next Frontier for 3D In Vitro Liver Toxicity Testing

Mechanisms of hepatotoxicity associated with the monocyclic β-lactam antibiotic BAL30072

The importance of inter-individual Kupffer cell variability in the governance of hepatic toxicity in a 3D primary human liver microtissue model

Transcriptomic, Proteomic, and Functional Long-term Characterization of Multicellular Three-Dimensional Human Liver Microtissues

Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury

Hepatic 3D spheroid models for the detection and study of compounds with cholestatic liability

Expression Analysis of Exosomal MicroRNAs in Chlorpromazine Treated Human Hepatic Spheroids: A Promising Tool for Novel Drug-Induced Liver Injury Biomarker Discovery