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- Liver Safety
InSphero & FDA's NCTR Peer-reviewed Paper | Physiological liver microtissue 384-well microplate system for preclinical hepatotoxicity assessment of therapeutic small molecule drugs
- Publication
- Liver Disease
Digital pathology with artificial intelligence analysis provides insight to the efficacy of anti-fibrotic compounds in human 3D MASH model
- Publication
- Liver Safety
Preclinical Characterization and Phase I Trial Results of INBRX-109, A Third-Generation, Recombinant, Humanized, Death Receptor 5 Agonist Antibody, in Chondrosarcoma
- Publication
- 3D Cell Culture Technology
miR-149 suppresses breast cancer metastasis by blocking paracrine interactions with macrophages
- Publication
- 3D Cell Culture Technology
Formation and optimization of three-dimensional organoids generated from urine-derived stem cells for renal function in vitro
- Publication
- 3D Cell Culture Technology
In vitro cell culture of patient derived malignant pleural and peritoneal effusions for personalised drug screening
- Publication
- 3D Cell Culture Technology
Generation of uniform liver spheroids from human pluripotent stem cells for imaging-based drug toxicity analysis
- Publication
- 3D Cell Culture Technology
Extra Cellular Matrix Deposition and Assembly in Dermis Spheroids
- Publication
- 3D Cell Culture Technology
Three-dimensional renal organoids from whole kidney cells: generation, optimization, and potential application in nephrotoxicology in vitro
- Publication
- 3D Cell Culture Technology
Microscale tissue engineering using gravity-enforced cell assembly
- Publication
- 3D Cell Culture Technology
A Novel Concept for Scaffold-Free Vessel Tissue Engineering: Self-Assembly of Microtissue Building Blocks
- Publication
- 3D Cell Culture Technology
Scaffold-free cell delivery for use in regenerative medicine
- Publication
- 3D Cell Culture Technology
Heterologous Protein Production Capacity of Mammalian Cells in 2D and 3D cultures
- Publication
- Liver Disease
A 3D primary human cell-based in vitro model of non-alcoholic steatohepatitis for efficacy testing of clinical drug candidates
- Publication
- Liver Disease
Particulate and drug-induced toxicity assessed in novel quadruple cell human primary hepatic disease models of steatosis and pre-fibrotic NASH
- Publication
- 3D Cell Culture Technology
Patient-derived tumor spheroid cultures as a promising tool to assist personalized therapeutic decisions in breast cancer
- Publication
- 3D Cell Culture Technology
Activated Cardiac Fibroblasts Control Contraction of Human Fibrotic Cardiac Microtissues by a -Adrenoreceptor-Dependent Mechanism
- Publication
- 3D Cell Culture Technology
Assessing the predictive response of a simple and sensitive blood-based biomarker between estrogen-negative solid tumors
- Publication
- Liver Safety
Multi-cell type human liver microtissues for hepatotoxicity testing
- Publication
- 3D Cell Culture Technology
A Framework for Optimizing High-Content Imaging of 3D Models for Drug Discovery
- Publication
- 3D Cell Culture Technology, Oncology & Immunology
Evaluation of assays for drug efficacy in a three-dimensional model of the lung
- Publication
- 3D Cell Culture Technology
A 3D co-culture microtissue model of the human placenta for nanotoxicity assessment
- Publication
- 3D Cell Culture Technology, Oncology & Immunology
Three-dimensional microtissues essentially contribute to preclinical validations of therapeutic targets in breast cancer
- Publication
- 3D Cell Culture Technology
Integrating Microtissues in Nanofiber Scaffolds for Regenerative Nanomedicine
- Publication
- 3D Cell Culture Technology, Oncology & Immunology
A 3D-microtissue-based phenotypic screening of radiation resistant tumor cells with synchronized chemotherapeutic treatment
- Publication
- 3D Cell Culture Technology
An in vitro osteosarcoma 3D microtissue model for drug development
- Publication
- 3D Cell Culture Technology, Oncology & Immunology
Additive impact of HER2-/PTK6-RNAi on interactions with HER3 or IGF-1R leads to reduced breast cancer progression in vivo
- Publication
- 3D Cell Culture Technology, Oncology & Immunology
Development of an innovative 3D cell culture system to study tumour–stroma interactions in non-small cell lung cancer cells
- Publication
- 3D Cell Culture Technology, Oncology & Immunology
3D cell culture systems modeling tumor growth determinants in cancer target discovery
- Publication
- 3D Cell Culture Technology, Oncology & Immunology
A High-Throughput–Compatible 3D Microtissue Co-culture System for Phenotypic RNAi Screening Applications
- Publication
- Liver Safety
Extending the limits of quantitative proteome profiling with data-independent acquisition and application to acetaminophen treated 3D liver microtissues
- Publication
- Liver Safety
Hepatic toxicology following single and multiple exposure of nanomaterials utilising a novel primary human 3D liver microtissue model
- Publication
- Liver Safety
Differential basolateral-apical distribution of scavenger receptor, class B, type I in cultured cells and the liver
- Publication
- Liver Safety
State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology
- Publication
- Liver Safety
Characterization of a Rat Multi-Cell Type 3D-Liver Microtissue System
- Publication
- Liver Safety
Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury
- Publication
- Liver Safety
Mechanisms of hepatotoxicity associated with the monocyclic β-lactam antibiotic BAL30072
- Publication
- Liver Safety
Hepatic 3D spheroid models for the detection and study of compounds with cholestatic liability
- Publication
- Oncology & Immunology
A novel three-dimensional heterotypic spheroid model for the assessment of the activity of cancer immunotherapy agents
- Publication
- Oncology & Immunology
Multiplexed Drug Assessment in 3D. Combining Luminescence and Fluorescence Genetic Reporters to Assess Drug Effects
- Publication
- Oncology & Immunology
Characterization and Drug Sensitivity Testing of HTS-Compatible Cancer Microtissues
- Publication
- Oncology & Immunology
Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety of cell types
- Publication
- Liver Safety
Expression Analysis of Exosomal MicroRNAs in Chlorpromazine Treated Human Hepatic Spheroids: A Promising Tool for Novel Drug-Induced Liver Injury Biomarker Discovery
- Publication
- Liver Safety
High-throughput transcriptomic analysis of human primary hepatocyte spheroids exposed to per- and polyfluoroalkyl substances (PFAS) as a platform for relative potency characterization
- Publication
- Liver Safety
Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations
- Publication
- Liver Safety
Translational Safety: The Next Frontier for 3D In Vitro Liver Toxicity Testing
- Publication
- Liver Safety
The importance of inter-individual Kupffer cell variability in the governance of hepatic toxicity in a 3D primary human liver microtissue model
- Publication
- Liver Safety
Transcriptomic, Proteomic, and Functional Long-term Characterization of Multicellular Three-Dimensional Human Liver Microtissues
- Publication
- Islet Biology
Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model
- Publication
- Islet Biology
Multifunctional in vivo imaging of pancreatic islets during diabetes development
- Publication
- Liver Disease
Considerations for engineering composable, disease-tunable 3D human microtissues for drug discovery
- Publication
- Islet Biology
Identification of proliferative and mature ß-cells in the islets of Langerhans
- Publication
- Islet Biology
Evaluation of the Effects of Harmine on β-cell Function and Proliferation in Standardized Human Islets Using 3D High-Content Confocal Imaging and Automated Analysis
- Publication
- Islet Biology
Improved physiological properties of gravity-enforced reassembled rat and human pancreatic pseudo-islets
- Publication
- Islet Biology
Liraglutide protects β-cells in novel human islet spheroid models of type 1 diabetes
- Publication
- Oncology & Immunology
Tracing Clonal Dynamics Reveals that Two-and Three-dimensional Patient-derived Cell Models Capture Tumor Heterogeneity of Clear Cell Renal Cell Carcinoma
- Publication
- Islet Biology
Effect of IL4 and IL10 on a human in vitro type 1 diabetes model
- Publication
- Islet Biology
Upregulation of HLA class II in pancreatic beta cells from organ donors with type 1 diabetes
- Publication
- Islet Biology
HIF-1alpha inhibitor PX-478 preserves pancreatic beta cell function in diabetes
- Publication
- Islet Biology
Translational assessment of a genetic engineering methodology to improve islet function for transplantation
- Publication
- Islet Biology
A microfluidic hanging-drop-based islet perifusion system for studying glucose-stimulated insulin secretion from multiple individual pancreatic islets
- Publication
- Islet Biology
Human Islet Microtissues as an In Vitro and an In Vivo Model System for Diabetes
- Publication
- Islet Biology
In Vitro Platform for Studying Human Insulin Release Dynamics of Single Pancreatic Islet Microtissues at High Resolution
- Publication
- Islet Biology
Targeted pharmacological therapy restores β-cell function for diabetes remission
- Publication
- Islet Biology
Glucose, Adrenaline and Palmitate antagonistically regulate insulin and glucagon secretion in human pseuodislets
- Publication
- Islet Biology
Targeted delivery of antisense oligonucleotides to pancreatic β-cells
- Publication
- 3D Cell Culture Technology
Evaluation of human liver microtissues for drug screening on schistosoma mansoni schistosomula
- Publication
- Liver Disease
sGC stimulator praliciguat suppresses stellate cell fibrotic transformation and inhibits fibrosis and inflammation in models of NASH
- Publication
- 3D Cell Culture Technology
The fibrotic response of primary liver spheroids recapitulates in vivo hepatic stellate cell activation
- Publication
- Liver Disease
Development and validation of an in vitro 3D model of NASH with severe fibrotic phenotype
- Publication
- 3D Cell Culture Technology
Predicting Metabolism-Related Drug–Drug Interactions Using a Microphysiological Multitissue System
- Publication
- 3D Cell Culture Technology
Microfluidic Multitissue Platform for Advanced Embryotoxicity Testing In Vitro
- Publication
- 3D Cell Culture Technology
Tubing-free microfluidic microtissue culture system featuring gradual, in vivo-like substance exposure profiles
- Publication
- 3D Cell Culture Technology
Scalable Microfluidic Platform for Flexible Configuration of and Experiments with Microtissue Multiorgan Models
- Publication
- 3D Cell Culture Technology
Microfluidic Hydrogel Hanging‐Drop Network for Long‐Term Culturing of 3D Microtissues and Simultaneous High‐Resolution Imaging
- Publication
- 3D Cell Culture Technology
Electrical impedance spectroscopy for microtissue spheroid analysis in hanging-drop networks
- Publication
- 3D Cell Culture Technology
Multi-analyte biosensor interface for real-time monitoring of 3D microtissue spheroids in hanging-drop networks
- Publication
- 3D Cell Culture Technology
Automated, multiplexed electrical impedance spectroscopy platform for continuous monitoring of microtissue spheroids
- Publication
- 3D Cell Culture Technology
Adding the “heart” to hanging drop networks for microphysiological multi-tissue experiments
- Publication
- 3D Cell Culture Technology
3D spherical microtissues and microfluidic technology for multi-tissue experiments and analysis
- Publication
- 3D Cell Culture Technology
96-well format microfluidic platform for parallel interconnection of multiple multicellular spheroids
- Publication
- 3D Cell Culture Technology
Reconfigurable microfluidic hanging drop network for multi-tissue interaction and analysis
- Publication
- Liver Disease