Efficient and precise liquid handling protocol with INTEGRA VIAFLO 96 and VIAFLO 384
3D human in vitro cell models have gained increased importance in the drug discovery and development cycle of the pharmaceutical industry, as they mimic the human in vivo responses of newly developed substances more precisely than 2D models. They bridge the gap between the traditional 2D in vitro models and whole-animal systems, as the conventional models do not effectively recapitulate the more complex signaling and cellular interactions found in vivo. Spheroids are scaffold-free 3D cell culture models aggregated from one or more organ-specific cell types.
InSphero has developed 3D cell-based assay solutions for Liver Safety, Liver Disease, Islet Biology, and Oncology. Industrial use of innovative in vitro systems requires a perfect match of the tissue model, cell culture plates, and liquid handling instrumentation. The Akura™ 96 and 384 Spheroid Microplates have been engineered for the generation, long-term cultivation, observation, and testing of spheroids in 96 and 384 well formats in a simple, flexible, and automation-compatible platform. Its scalable format requires liquid handling systems for convenient, yet quick, reliable, and precise medium exchange, sampling, dosing, and spheroid transfer from multiple plates. The semiautomated VIAFLO 96 and VIAFLO 384 electronic pipettes from INTEGRA are ideal for these routine lab tasks, offering 96 and 384 channels pipetting in a compact and easy-to-use platform, for increased productivity.