3D InSightâ„¢ Human Liver Microtissues:
Assay-ready liver spheroids
A turnkey screening solution for in-house liver safety assessment


3D InSightâ„¢ Human Liver Microtissues | Assay-ready liver spheroids for in-house testing
3D InSightâ„¢ Human Liver Microtissues is the gold standard for liver safety assessment. These pharma-validated, preclinical co-culture liver models have been shown to achieve 2x higher sensitivity for Drug induced liver injury (DILI) prediction compared to traditional 2D hepatocytes.
- Reflect the average response of a population with a model incorporating hepatocytes from 5 male and 5 female donors
- Achieve the highest biological relevance with an in vitro model including both parenchymal and non-parenchymal liver cells.
- Test up to 28-day effects of drug exposure in a stable, organotypic, functional liver model
- Highly reproducible and robust liquid handling in InSphero’s patented Akura™ 96 plates (engineered to protect microtissues from accidental aspiration and minimize residual cell culture media volumes)
- Complete turnkey solutions offer lower cost-of-ownership than in-house production
By combining multi-donor diversity with structural and functional robustness, our models are ideal for drug safety and efficacy testing as well as the study of healthy and diseased liver function.
- InSphero Liver models come with a suite of 3D InSightâ„¢ Cell-Culture Media, optimized and tailored to match your scientific applications.
- 3D InSightâ„¢ TOX Liver Medium: Optimized for maintain phase I metabolism for the safety assessment of small molecules
- 3D InSightâ„¢ INF Liver Medium: Optimized for the immuno-competency of the models
- 3D InSightâ„¢ Lean Liver Medium: Optimized for the study of metabolic processes
InSphero recommends the use of the Incuboxâ„¢ when cultivating 3D InSightâ„¢ liver models to minimize edge effects. Click here to find more information on Incuboxâ„¢
Technical Specifications
Shipping Assay-ready Human Liver Microtissues
Production Schedule
Technical Specifications
- PHH from pooled male/female donors
- Co-culture with Kupffer cells and LECs
- Guaranteed 28 days viability
- 96-well format, 1 microtissue per well
- Delivered with min. 50 mL of 3D InSightâ„¢ Liver Maintenance Medium
- Biweekly production. Check our online production schedule for details
- Shipping date to be confirmed by our customer service team after checkout
Shipping Assay-ready Human Liver Microtissues
Microtissues are shipped in our InFloatâ„¢ Shipping System which includes our Akuraâ„¢ 96 plates (one microtissue per well), with 3D InSightâ„¢ Human Liver Microtissue Maintenance Medium - AF/TOX, our recommended media for routine culture and maintenance of liver microtissues.
Production Schedule
Product Documents
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