Discover Akura™ Twin Organ-on-Chip Platform
The Akura™ Twin Organ-on-Chip Platform is designed for organ-organ cross-talk in the presence of immune cells with robust handling as well as reliable culturing and analysis.
Akura™ Twin OoC Applications
Address present challenges in drug development:
- Add immune competence to your 3D cell-based assays
- Study organ-organ cross-talk with side-by-side co-culturing of different spheroids
- Investigate immune cell / 3D tissue interaction at scale
Akura™ Twin OoC Plate Layout
- The plate is based on the Akura™ 384 Spheroid Microplate and includes the unique SureXchange™ ledge engineered to prevent unintended spheroid/organoid and cell aspiration
- A microchannel connects two adjacent wells enabling soluble factors and single (immune) cells to travel between both wells while the spheroid/organoid remains in its dedicated well
- A unique ULA coating in the well and microchannel preserves spheroid/organoid morphology and prevent immune cell adhesion in long-term culture
- Enhanced imaging speed and resolution through flat and highly transparent bottom well
Experience an innovative and intuitive well architecture:
- One spheroid/organoid per 1-mm diameter well for evident detection and registration
- Conical well design with SureXchange™ ledge protecting the spheroid/organoid cells from aspiration while leaving a minimal residual volume (5-7 ul)
- Simple microfluidic channel for robust and efficient medium flow and cell movement
- Near-complete medium exchange for precise dosing and low experimental variation
Rely on universal plate standards:
- ANSI/SLAS standard format for quick implementation with widely used lab tools
- Tube-free perfusion by using gravity-based flow on parallel plate rocker
- Full compatibility and with automation and robotic liquid handlers
Access a wide range of readout methods:
- Anytime access to supernatants using manual or automated pipetting
- Simple and parallel retrieval of spheroids for lytic assays, histology or RNA sequencing
- In-situ high-content imaging with minimal optical aberration with a flat and highly transparent COP bottom
Akura™ Twin Organ-on-Chip Platform Workflow
Akura™ Twin OoC Starter Kit
Bring Akura™ Twin Organ-on-Chip Platform into your lab by acquiring our starter kit offering. It’s everything you need to immediately begin investigating complex biological questions in your research:
Akura™ Flow Programmable All-In-One Tilter
Controls gravity-based flow in incubator with intuitive built-in user interface
5x Pack of Akura™ Twin Microplates
Pack of 5 plates for up to 192 experimental conditions per plate
Akura™ Tilting Stand
Simple handling tool providing gravity-based flow while performing medium exchange under the hood.
20x Pack of Akura™ 96 Microplate
For 3D spheroid aggregation before transferring into Akura™ Twin or for collection after experiments and downstream analysis
1h Akura™ e-Introduction
Learn about concept, design and characteristics of the Akura™ Twin Platform.
Akura™ Organ-on-Chip Training & Support
Personal support and consulting to set up the first experiments with InSphero’s scientific experts.
Akura™ Organ-on-Chip Technology Access Package
Allows for discounted Refills & Voucher (2000 CHF) for InSphero products (valid 6 months)
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