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Akura™ Twin Microplate
The Akura™ Twin Microplate is designed for organ-organ cross-talk in the presence of immune cells with robust handling as well as reliable culturing and analysis.
- The plate is based on the Akura™ 384 Spheroid Microplate and includes the unique SureXchange™ ledge engineered to prevent unintended spheroid/organoid and cell aspiration
- A microchannel connects two adjacent wells enabling soluble factors and single (immune) cells to travel between both wells while the spheroid/organoid remains in its dedicated well
- A unique ULA coating in the well and microchannel preserves spheroid/organoid morphology and prevent immune cell adhesion in long-term culture
- Enhanced imaging speed and resolution through flat and highly transparent bottom well
Application
Architecture
Handling
Application
Address present challenges in drug development:
- Add immune competence to your 3D cell-based assays
- Study organ-organ cross-talk with side-by-side co-culturing of different spheroids
- Investigate immune cell / 3D tissue interaction at scales
Architecture
Experience an innovative and intuitive well architecture:
- One spheroid/organoid per 1-mm diameter well for evident detection and registration
- Conical well design with SureXchange™ ledge protecting the spheroid/organoid cells from aspiration while leaving a minimal residual volume (5-7 µl).
- Simple microfluidic channel for robust and efficient medium flow and cell migration
- Near-complete medium exchange for precise dosing and low experimental variation
Handling
Rely on universal plate standards:
- ANSI/SLAS standard format for quick implementation with widely used lab tools
- Tube-free perfusion by using gravity-based flow on parallel plate rocker
- Full compatibility and with automation and robotic liquid handlers
Read out
Access a wide range of read out methods:
- Anytime access to supernatants using manual or automated pipetting
- Simple and parallel retrieval of spheroids for lytic assays, histology or RNA sequencing
- In-situ high-content imaging with minimal optical aberration with a flat and highly transparent COP bottom
Akura™ Twin Starter Kit
Bring Akura™ Twin Microplate into your lab by acquiring our starter kit offering. It’s everything you need to immediately begin investigating complex biological questions in your research:
- 5x Akura™ Twin Microplate
- 20x Akura™ 96 Spheroid Microplate
- 1x 1h Akura™ e-Introduction Session
- 2x 1h Training (before and after first use)
- Akura™ Flow Programmable All-In-One Tilter
- Technology access package for 6 months
- 2000 USD/EUR/CHF token for purchasing InSphero Products
- Special discount on additional 5x Akura™ Twin Microplate
Product Documents
