Menu
3D InSight™ NAFLD (MASLD) Model for Screening and Discovery
Understand the biology of fatty liver disease and screen for small molecules and biologicals - all in the same in vitro platform.
Leveraging InSphero's market-leading 3D InSight™ NASH (MASH) model, our NAFLD (recently renamed to MASLD - Metabolic Dysfunction-associated Steatotic Liver Disease) platform offers equivalent advantages for fatty liver disease research. Experience a high-quality, scalable, and human-relevant 3D in vitro disease model that generates precise insights and facilitates efficient research throughput. Rely on our expertise in creating primary-cell spheroid models and inducing specific disease phenotypes, enabling us to tailor solutions to your needs - faster and more efficiently than anyone else.
Why NAFLD Screening with InSphero?
We inspire researchers, worldwide, to reach their full potential so that life changing therapies can ultimately make it into the hands of patients.
Predictive and robust human liver biology you can trust
As complex as necessary and as simple as possible. Our research credo at work. Based on co-culturing disease relevant primary cells, our model mimics NAFLD accurately
Continuity from screening to mechanistic research
Our NAFLD model is not only great for mechanistic research, it is also perfect for automated screening on all automation platforms
Understand the impact of genetic variants (SNPs)
3D InSight™ NAFLD models are available in multi-donor form or based on single donors including metabolically relevant SNPs (e.g., PNPLA3, HSD17B13)
10x faster results get you closer to the cure
10x faster, that is the time you save going in vitro instead of animal models. Faster data, more insights, quicker iterations to find and assess your compound
Our Process
3D InSight™ Liver Microtissue formation
Primary human hepatocytes (PHHs), Kupffer cells, and liver endothelial cells (LECs)
Lipid loading
Using an optimized treatment with free fatty acids and elevated sugar concentration
Compound dosing
Multiple compound addition steps to mimic regular intake
Multiparametric readouts
Quantification of lipid content using biochemical or advanced imaging assays
Previous slide
Next slide
