Akura™ Flow Organ-on-Chip Platform
The Akura™ Flow Organ-on-Chip Platform is a multi-organ system engineered to be compatible with spheroids and organoids including our complete portfolio of 3D InSight™ Microtissues.
Originating from prototypes conceived in the EU “Body-on-a-Chip” Project, the platform's flexibility opens the door to a range of pre-clinical efficacy and toxicity testing applications in a multi-tissue, microfluidic assay format. The Akura™ Flow microphysiological system (MPS) provides experimental continuity between single- and multi-tissue testing applications, enabling the seamless integration and optimal utilization of standardized 3D models.
Discover Akura™ Flow Organ-on-Chip
- 2 units per chip, each comprising 10 compartments for flexible combination of different organ models
- 4 chips assembled in a holder plates complying with SLAS/ANSI format enabling spheroid/organoid to be loaded through pick-and-place using automated liquid handlers
- A unique ULA coating in the compartments and microchannel preserves spheroid/organoid morphology in long-term culture
- Imaging accessibility through flat and transparent bottom
Experience a highly flexible multi-organ platform:
- Conical well design with SureXchange™ ledge for easy gravity-based loading and access of spheroids
- Quick plug-and-play assembly of different microtissue types and seamless integration of additional models in the future
- Spheroid compartment with minimal dead volume enabling very precise medium exchange and drug treatment and low experimental variation
Rely on plate standards and low operational complexity:
- ANSI/SLAS standard format for quick implementation with widely used lab tools
- Convenient for manual use and compatibility with (semi-)automation and robotic liquid handlers
- Gravity-based and pumpless flow control for simple plate handling
Access a wide range of readout methods with Akura™ Flow Organ-on-Chip MPS:
- Anytime access to supernatants though easy accessible reservoirs
- Retrieval of spheroids for lytic assays, histology or RNA sequencing
- In-situ high-content imaging with minimal optical aberration with a flat and transparent polystyrene bottom
Applications of Akura™ Flow Organ-on-Chip Platform
- Signaling between Healthy and Diseased Tissue
- Pro-drug Activation and Drug-drug Interaction
- Metabolite Toxicity on On-target and Off-target Tissues
- Metabolite Disease Syndrome modeling combining for example liver, islet and adipose models
Akura™ Flow Organ-on-Chip Starter Kit
Bring Akura™ Flow Organ-on-Chip System into your lab by acquiring our starter kit offering. It’s everything you need to immediately begin investigating complex biological questions in your research.
Akura™ Flow Programmable All-In-One Tilter
Controls gravity-based flow in incubator with intuitive built-in user interface.
2x Akura™ Flow Kit (2/pack)
4 frames, each with 4 chips and supplements to run an experiment with up to 32 experimental conditions.
2x Akura™ Flow Refill (2/pack)
16 chips and supplements to run an experiment with up to 32 conditions.
Akura™ Tilting Stand
Simple handling tool providing gravity-based flow while performing medium exchange under the hood.
20x Pack of Akura™ 96 Microplate
For 3D spheroid aggregation before transferring into Akura™ Flow or for collection after experiments and downstream analysis.
1h Akura™ e-Introduction
Learn about concept, design and characteristics of the Akura™ Flow OoC Platform.
Akura™ Organ-on-Chip Training & Support
Personal support and consulting to set up the first experiments with InSphero’s scientific experts.
Akura™ Organ-on-Chip Technology Access Package
Allows for discounted Refills & Voucher (2000 CHF) for InSphero products (valid 6 months)
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