Contact Us to learn how you can leverage our 3D InSight™ Human Liver Microtissues for toxicity testing in your drug discovery pipeline.
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Fail fast, fail smart! Assess the Risk of Liver Injury Due to Toxic Compound Exposure with 3D InSight™ Human Liver Microtissues
3D InSight™ Human Liver Microtissues are pharma-validated, preclinical co-culture human liver models for toxicology testing that have been shown to achieve 2X higher sensitivity for DILI prediction compared to traditional 2D PHH.
These advanced 3D liver models, which combine multi-donor diversity with structural and functional robustness, are ideal for drug safety and efficacy testing as well as the study of healthy and diseased liver function.
Upon request, microtissues from individual donor hepatocyte lots are also available.
- Closely reflect the average response of the human population with a model incorporating hepatocytes from 5 male and 5 female donors
- Achieve the highest biological relevance in an in vitro co-culture model of primary human hepatocyte, Kupffer cell, and liver endothelial cell (LEC)
- Test long-term effects of drug exposure in a more reliable way to reflect the human response and potential for drug-induced liver injury
- Investigate mechanisms of liver injury and drug-induced liver pathologies, such as necrosis, apoptosis, cholestasis, steatosis, inflammation, and fibrosis.
- Save time and in-house resources with fully validated and quality-controlled 3D liver models shipped direct to your lab, ready to assay within hours of receipt – or send us your compounds, and our expert liver toxicology team will screen and assess drug risk using our proven 3D liver models for you!
Characterization Data
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Human Liver Microtissue Specifications
- PHH from pooled male/female donors
- Co-culture with Kupffer cells and LECs
- Guaranteed 28 days viability
- 96- or 384-well format, 1 microtissue per well
- Biweekly production
Order Information
| Catalog # | Description |
|---|---|
| Microtissues | |
| MT-02-302-04 | 3D InSight™ Human Liver Microtissues (multi-donor hepatocytes, co-culture with Kupffer cells and LECs), 96x |
| MT-02-302-04-384 | 3D InSight™ Human Liver Microtissues (multi-donor hepatocytes, co-culture with Kupffer cells and LECs), 384x |
| MT-02-302-01 | 3D InSight™ Human Liver Microtissues (multi-donor hepatocytes, monoculture), 96x |
| MT-02-302-01-384 | 3D InSight™ Human Liver Microtissues (multi-donor hepatocytes, monoculture), 384x |
| MT-02-002-04 | 3D InSight™ Human Liver Microtissues (single-donor hepatocytes, co-culture with Kupffer cells and LECs), 96x |
| MT-02-002-01 | 3D InSight™ Human Liver Microtissues (single-donor hepatocytes, monoculture), 96x |
| Media* | |
| CS-07-001-01 | Maintenance Medium – TOX* (for tox testing), 500 mL |
| CS-07-001a-01 | Maintenance Medium – AF* (for basic cultivation), 500 mL |
| CS-07-001b-01 | Maintenance Medium – INF* (for inflammatory tox testing), 500 mL |
* only available when purchased with 3D InSight™ Microtissues
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