3D InSight™ Translational Toxicology Service | 3D In Vitro Liver Safety Services
Early identification of species-specific adverse drug effect based on market-leading 3D Liver Safety Platform
Industry-ready 3D In Vitro Translational Toxicology
Do you have conflicting data from your studies and need to determine which species best represent human responses?
InSphero's translational toxicology services enable you to assess pre-clinical susceptibility to drug-induced hepatotoxicity across various species. Our 3D InSight™ XSpecies Liver Microtissues of the most common preclinical animal species mimic the architecture and functionality of liver tissue in a 3D spheroid format. We carefully select species-specific primary hepatocytes and co-culture them with non-parenchymal liver cells, effectively modeling key liver functions.
Why 3D In Vitro Translational Testing with InSphero?
We enable liver safety researchers to tease out species-specific toxic effect with comparison of human and animal response through scalable, reliable and reproducible 3D in vitro models and advanced scientific expertise.
Embrace the 3R’s with 3D in vitro models
Replace, reduce and refine animal studies by pre-testing with scalable species-specific 3D in vitro models.
Elevate Preclinical Safety Assessment
Successfully unravel interspecies differences with InSphero’s liver microtissues - the only 3D in vitro liver model containing all key liver cell types. Primary species-specific parenchymal and non-parenchymal cells provide you with a reliable and physiological system.
Seamless transition from predictive to investigative toxicology when needed
Identified species-specific toxicity? Our team swiftly advances your compound from 7-day DILI service to investigative options, like transcriptomic analysis or mechanistic assays, to uncover its mechanism of toxicity.
Fast turnaround to accelerate your projects
Our streamlined, automated, and 3D-optimized workflow guarantees reliable data in record time.
Our 3D InSight™ XSpecies Liver Microtissues
Rat model
3D InSight™ Rat Liver Microtissues are multi-donor Sprague-Dawley primary hepatocytes co-cultured with primary crude non-parenchymal cells from the same strain.
Mouse model
3D InSight™ Mouse Liver Microtissues are multi-donor C57/BL6 primary hepatocytes co-cultured with primary crude non-parenchymal cells from the same strain.
Dog model
3D InSight™ Dog Liver Microtissues are single-donor Beagle primary hepatocytes co-cultured with single-donor Beagle primary crude non-parenchymal cells.
Monkey model
3D InSight™ Monkey Liver Microtissues are single-donor Cynomolgus primary hepatocytes in co-culture with single-donor Cynomolgus primary crude non-parenchymal cells.
Our XSpecies Translational Toxicology Process
Expert project planning
Our liver safety experts will collaborate with you to devise the optimal strategy for your case.
Convenient compound shipping
Send us your compounds. We'll monitor the shipment while the 3D liver microtissues are in preparation.
Long-term translational toxicology studies
Our models support 7-day translational studies with repeated compound applications.
Comprehensive reporting
Our detailed report equips you with everything needed to effectively present the results to your organization and support your next steps in decision-making.
