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- Poster
- Liver Safety
Liver Microtissues – A Highly Reproducible In Vitro Test System for Safety Assessment of Small Molecules
- Poster
- Liver Safety
Leveraging Human, Animal Liver Microtissues and Low-Input RNA-Sequencing to Characterize Mechanisms of Drug-Induced Liver Injury
- Webinar
- Liver Safety
The 3D InSight™ Liver Microtissues Platform a Versatile Tool for In Vitro Hepatotoxicity Studies
- Publication
- Liver Safety
Nucleophosmin 1 induction is an early event in a Phenobarbital induced proliferation response in rat but not human liver 3D microtissues
- Publication
- Liver Safety
Cross-species comparison of CAR-mediated procarcinogenic key events in a 3D liver microtissue model
- Publication
- Liver Safety
Assessing the impact of perfluoroalkyl substances on liver health: a comprehensive study using multi-donor human liver spheroids
- Publication
- Liver Safety
New approach methodologies (NAMs) for drug-induced liver injury (DILI): Where are we now?
- Publication
- Liver Safety
Toxicity of ubiquitous tire rubber antiozonant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its transformation product 6PPD-quinone (6PPD-Q) in primary human hepatocytes and liver spheroids
- Poster
- Liver Disease
The lipid synthesis inhibitors ACC (Firsocosat) and DGAT2 (Ervogastat) reduce triglyceride contentindependently, but only Ervogastat also reduces fibrosis biomarkers in human liver spheroids
- Application Note
- 3D Cell Culture Technology
High-throughput modeling of inflammatory bowel disease using human intestinal organoids
- Poster
- 3D Cell Culture Technology, Liver Safety
Multiparameter-based assays in 3D human liver microtissues: Towards multiplexed in vitro NAMs for drug-induced liver injury (DILI) assessment
- Publication
- 3D Cell Culture Technology, Oncology & Immunology
A microfluidic platform for the co-culturing of microtissues with continuously recirculating suspension cells
- Poster
- 3D Cell Culture Technology, Liver Disease
Machine learning-based, label-free detection of anti-fibrotic effects in a 3D retinal fibrosis model using bright-field imaging
- Poster
- Liver Disease, Liver Safety
Application of InSight™ human 3D MASLD/MASH spheroid models for DILI assessment of compounds
- Poster
- Oncology & Immunology
Recapitulating Tumor Complexity In Vitro: A High-Throughput 3D Microtissue Platform for Oncology Drug Screening and Validation
- Publication
- 3D Cell Culture Technology, Liver Disease, Liver Safety
Sweet and sticky: increased cell adhesion through click-mediated functionalization of regenerative liver progenitor cells
- Publication
- 3D Cell Culture Technology, Oncology & Immunology
A Framework for Optimizing High-Content Imaging of 3D Models for Drug Discovery
- Publication
- 3D Cell Culture Technology, Oncology & Immunology
A 3D Heterotypic Multicellular Tumor Spheroid Assay Platform to Discriminate Drug Effects on Stroma versus Cancer Cells
- Publication
- 3D Cell Culture Technology, Oncology & Immunology
Preclinical Development of T Cells Engineered to Express a T-Cell Antigen Coupler Targeting Claudin 18.2–Positive Solid Tumors
- Poster
- Oncology & Immunology
Bridging the Gap Between In Vitro and In Vivo : STC-1010 Cancer Vaccine Efficacy in 3D Tumor Spheroids
- Video
- 3D Cell Culture Technology
Automated Processing of ARCTis™ - Always Ready Cryo Tissues with CyBio Felix®
- Poster
- Oncology & Immunology
Development of the in vitro 3D Spheroid High-Throughput Screening Platform for the Development of Immune Checkpoint Inhibitors
- Brochure
- Oncology & Immunology
Revolutionizing Pre-clinical Drug Discovery and Screening with 3D InSight™ Patient-derived Primary Tumor Spheroids Platform
- Brochure
- Oncology & Immunology
Innovation in 3D In Vitro Oncology: Novel Insights and Reproducible Results with Data-Driven Antibody Penetration Study
- Poster
- Oncology & Immunology
Unlocking the potential of 3D patient-derived tumor microtissues as reliable and scalable in vitro pre-clinical models
- Publication
- Liver Safety
TAK-994 mechanistic investigation into drug-induced liver injury
- Publication
- Liver Safety
Transcriptomic analysis in liver spheroids identifies a dog-specific mechanism of hepatotoxicity for amcenestrant
- Publication
- Liver Safety
Deciphering per- and polyfluoroalkyl substances mode of action: comparative gene expression analysis in human liver spheroids
- Publication
- Liver Safety
Multi-organ model assessment of neurotoxicity following exposure of liver spheroids to drugs
- Poster
- Oncology & Immunology
Scalable and Reproducible 3D Tumor Spheroid Models for Assessing Therapeutic Antibody Penetration and Efficacy
- Webinar
- Oncology & Immunology
Accelerate Your Oncology Research Through Assay-Ready Cryopreserved Tumor Tissues
- Poster
- Liver Disease
Screening and comparison of current clinical candidates and various modalities in MASH using human liver spheroids
- Poster
- Liver Safety
Species-specific Liver Microtissues: A Set Of Microphysiological Systems To Assess Translational Hepatotoxicity In Drug Development
- Poster
- Oncology & Immunology
A Novel Microplate Format for Tumor Cell Cryopreservation and 3D Tumor Spheroids Formation to Streamline Pre-clinical Drug Testing
- Publication
- Liver Safety
InSphero & FDA's NCTR Peer-reviewed Paper | Physiological liver microtissue 384-well microplate system for preclinical hepatotoxicity assessment of therapeutic small molecule drugs
- Video
- 3D Cell Culture Technology
InSphero’s Mission to Reduce Animal Testing in Drug Discovery - an Interview with LSCV
- Poster
- Liver Safety
Early Detection of Hepatotoxic Compounds in Drug Development: Leveraging the Potential of Human Liver Microtissues for Predictive Screening
- Application Note
- 3D Cell Culture Technology
Automated Tumor Spheroid Handling on the epMotion® 5073t using InSphero Akura™ Plates
- Publication
- Liver Disease
Digital pathology with artificial intelligence analysis provides insight to the efficacy of anti-fibrotic compounds in human 3D MASH model
- Poster
- 3D Cell Culture Technology
Assessment of cancer metastatic potential in Akura™ Immune Flow Platform
- Webinar
- 3D Cell Culture Technology, Liver Safety
The 3D DILI Model of Success – from Biological Relevance to Industry Application
- Poster
- 3D Cell Culture Technology, Liver Disease
Scalable 3D Cell Culture-based Retinal Fibrosis Model for Efficacy Testing
- Poster
- Oncology & Immunology
Assess the effects of tumor-dendritic cell reprogramming, using the 3D InSight™ Oncology and Immunology Platform
- Webinar
- 3D Cell Culture Technology, Oncology & Immunology
Advancing Oncology and Immune-Oncology Therapeutic Development Using 3D Tumor Spheroids
- Poster
- Liver Disease
Digital pathology with artificial intelligence analysis provides insight to the efficacy of anti-fibrotic compounds in human 3D MASH model
- Poster
- 3D Cell Culture Technology
Extending the choice of ULA plates for primary 3D human liver spheroid formation and experimentation with the Akura™ Spheroid Microplates
- Poster
- 3D Cell Culture Technology
Deciphering Metabolic Cross-Talk: Insights into Liver-Islet Interactions with human Microtissues and scalable Microphysiological Systems
- Application Note
- 3D Cell Culture Technology
Enhancing Scalability and Quality of 3D In Vitro Cell Models Production through Automation
- Poster
- 3D Cell Culture Technology, Oncology & Immunology
Assessment of immune cell infiltration and cancer metastatic potential in Akura™ Immune Flow Chip - A microfluidic 3D spheroid system
- Brochure
- Oncology & Immunology
3D InSight™ Tumor Spheroids: Balancing Physiological Relevance with Scalability and Reliability in Oncology Therapeutic Testing
- Brochure
- Oncology & Immunology
Human 3D InSight™ Tumor Spheroids: Reliable and Scalable In Vitro System to Model Immune Responses and Evaluate Cancer Immunotherapeutics
- Brochure
- Oncology & Immunology
Innovation in 3D In Vitro Oncology: Novel Insights and Reproducible Results with Data-Driven ADC Penetration Study
- Poster
- Oncology & Immunology
New microplate platform with cryopreserved 3D tumor spheroids for faster and convenient pre-clinical testing
- Poster
- 3D Cell Culture Technology, Liver Safety, Oncology & Immunology
Mitigation of liver toxicity effects of bispecific T cell engagers in immune-competent liver-tumor co-culturing high-throughput platform
- Poster
- Liver Safety
Initial evaluation of the use of human liver microtissues for the hepatotoxicity assessment of antisense oligonucleotides
- Poster
- Liver Disease
Patient-derived steatotic hepatocytes reveal non-cell autonomous inflammation and fibrogenic effects in multicellular liver spheroids
- Video
- 3D Cell Culture Technology, Oncology & Immunology
ARCTis™ Cryo Tissues - How to prepare plate
- Webinar
- 3D Cell Culture Technology, Oncology & Immunology
Predicting Metabolism-Related Drug-Drug Interactions with Organ-on-a-Chip Technology
- Webinar
- 3D Cell Culture Technology
Scalable 3D Cell Culture Technologies Engineered for Physiological InSight
- Webinar
- 3D Cell Culture Technology
Implementing High Resolution, High Content Image Analysis with Multicellular 3D Spheroid Models
- Webinar
- 3D Cell Culture Technology
Optimizing High-Content Imaging of 3D Models for Drug Discovery
- Webinar
- Liver Safety
Optimizing 3D Spheroid Models for Efficient Drug-Induced Liver Injury Screening
- Webinar
- Islet Biology
A Novel, High-Resolution Perifusion Platform for Studying Insulin Release Dynamics of Single Human Pancreatic Islets
- Webinar
- Liver Disease
Redefining NASH Drug Discovery: A New Approach to Complex Disease Modeling
- Webinar
- Liver Disease
Artificial Intelligence in Digital Pathology: Quantification of Fibrosis in Human 3D NASH Model
- Video
- 3D Cell Culture Technology
InSphero and Hamilton collaborate to improve the production and handling of spheroids
- Video
- Islet Biology
3D InSight™ Human Islet Microtissues as an in vitro and an in vivo model system for Type 1 and Type 2 Diabetes
- Video
- Liver Disease
Human 3D in vitro NASH model for efficacy testing of clinical drug candidates
- Video
- 3D Cell Culture Technology
Manual medium exchange under 2 minutes with InSphero Akura™ 96 Spheroid Microplate
- Video
- 3D Cell Culture Technology
InFloat™ Shipping Solution for 3D InSight™ Assay-ready Microtissues
- Video
- Liver Disease
How we applied InSphero technology to create a human liver NASH model
- Publication
- 3D Cell Culture Technology
Three-dimensional renal organoids from whole kidney cells: generation, optimization, and potential application in nephrotoxicology in vitro
- Publication
- 3D Cell Culture Technology
Extra Cellular Matrix Deposition and Assembly in Dermis Spheroids
- Publication
- 3D Cell Culture Technology
Generation of uniform liver spheroids from human pluripotent stem cells for imaging-based drug toxicity analysis
- Publication
- 3D Cell Culture Technology
In vitro cell culture of patient derived malignant pleural and peritoneal effusions for personalised drug screening
- Publication
- 3D Cell Culture Technology